Browsing Pharmacy Research by Author "n 94093771"
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Deciphering the complexities of cancer cell immune evasion: Mechanisms and therapeutic implications
Gupta, Ishita; Hussein, Ola; Sastry, Konduru Seetharama; Bougarn, Salim; Gopinath, Neha; Chin-Smith, Evonne; Sinha, Yashi; Korashy, Hesham Mohamed; Maccalli, Cristina... more authors ... less authors ( Elsevier , 2023 , Article Review)Cancer immune evasion is one of the principal mechanisms leading to the progression and metastatization of the disease. Despite the migration and infiltration at the tumor site of immune cells, multiple factors can influence ... -
Haematococcus pluvialis Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer Cells
Alateyah, Nouralhuda; Ahmad, Salma M. S.; Gupta, Ishita; Fouzat, Arij; Thaher, Mahmoud Ibrahim; Das, Probir; Al Moustafa, Ala-Eddin; Ouhtit, Allal... more authors ... less authors ( Frontiers Media S.A. , 2022 , Article)Breast cancer (BC) is the most common malignant cancer in females worldwide. Drug resistance, toxicity, and the failure of current therapies to completely cure BC has challenged conventional medicine. Consequently, ... -
Naked Poly(amidoamine) Dendrimer Nanoparticles Exhibit Intrinsic Embryotoxicity During the Early Stages of Normal Development.
Kheraldine, Hadeel; Gupta, Ishita; Alhussain, Hashim; Jabeen, Ayesha; Akhtar, Saghir; Al Moustafa, Ala-Eddin; Rachid, Ousama... more authors ... less authors ( American Science Publishers ASP , 2020 , Article)To investigate the impact of poly(amidoamine) dendrimers (PAMAMs) in the embryo, we explored the outcome of different generations (G₄ and G) on the early stages of embryogenesis using the chicken embryo as a model. We also ... -
Substantial cell apoptosis provoked by naked PAMAM dendrimers in HER2-positive human breast cancer via JNK and ERK1/ERK2 signalling pathways
Hadeel, Kheraldine; Gupta, Ishita; Alhussain, Hashim; Jabeen, Aayesha; Cyprian, Farhan S.; Akhtar, Saghir; Al Moustafa, Ala-Eddin; Rachid, Ousama... more authors ... less authors ( Elsevier , 2021 , Article)HER2-positive breast cancer is one of its most challenging subtypes, forming around 15–25% of the total cases. It is characterized by aggressive behavior and treatment resistance. On the other hand, poly (amidoamine) (PAMAM) ...