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Bone marrow mesenchymal stem cells preconditioned with nitric-oxide-releasing chitosan/PVA hydrogel accelerate diabetic wound healing in rabbits
(
IOP Publishing Ltd
, 2021 , Article)
Impaired diabetic wounds are one of the major pathophysiological complications caused by persistent microbial infections, prolonged inflammation, and insufficient angiogenic responses. Here, we report the development of ...
Experimental study on the mechanical properties of biological hydrogels of different concentrations
(
IOS Press BV
, 2020 , Article)
BACKGROUND: Biological hydrogels provide a conducive three-dimensional extracellular matrix environment for encapsulating and cultivating living cells. Microenvironmental modulus of hydrogels dictates several characteristics ...
Advances of exosome isolation techniques in lung cancer
(
Springer Science and Business Media B.V.
, 2020 , Article)
Lung cancer (LC) is among the leading causes of death all over the world and it is often diagnosed at advanced or metastatic stages. Exosomes, derived from circulating vesicles that are released from the multivesicular ...
Secondary metabolites from acridocarpus orientalis inhibits 4T1 cells and promotes mesenchymal stem cells (MSCs) proliferation
(
Springer
, 2020 , Article)
Abstract: Among medicinal plants, Acridocarpus orientalis (AO) possesses a remarkable anti-cancer potential, possibly because of its anti-oxidant property. In this study, the leaf and stem extracts from AO were assessed ...
Recent advances in 3D bioprinting of musculoskeletal tissues
(
IOP Publishing Ltd
, 2021 , Article)
The musculoskeletal system is essential for maintaining posture, protecting organs, facilitating locomotion, and regulating various cellular and metabolic functions. Injury to this system due to trauma or wear is common, ...
Development of remdesivir repositioning as a nucleotide analog against COVID-19 RNA dependent RNA polymerase
(
Taylor and Francis Ltd.
, 2020 , Article)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative representative of a severe respiratory illness resulted in widespread human infections and deaths in nearly all of the countries since late 2019. ...
Non-viral delivery systems of DNA into stem cells: Promising and multifarious actions for regenerative medicine
(
Editions de Sante
, 2020 , Article)
Regenerative medicine has an exciting prospective to bring preventive and therapeutic benefits to a myriad of diseases. Different biological factors such as growth factors, therapeutic proteins, antibodies, plasmid DNA ...
Vitamin K1 as a potential molecule for reducing single-walled carbon nanotubes-stimulated �-synuclein structural changes and cytotoxicity
(
Dove Medical Press Ltd.
, 2019 , Article)
Aims: Different kinds of vitamins can be used as promising candidates to mitigate the structural changes of proteins and associated cytotoxicity stimulated by NPs. Therefore, the structural changes of �-syn molecules and ...
Cerium Oxide Nanoparticle-Loaded Gelatin Methacryloyl Hydrogel Wound-Healing Patch with Free Radical Scavenging Activity
(
American Chemical Society
, 2021 , Article)
Nonhealing wounds in diabetic patients are a critical challenge, which often cause amputation and mortality. High levels of oxidative stress and aberrations in antioxidant defense mechanisms increase the adverse manifestations ...
An engineered microfluidic blood-brain barrier model to evaluate the anti-metastatic activity of β-boswellic acid
(
John Wiley and Sons Inc
, 2021 , Article)
Background
The development of anti-cancer drugs with the ability to inhibit brain metastasis through the blood-brain barrier (BBB) is substantially limited due to the lack of reliable in vitro models.
Main Methods
In ...