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Now showing items 11-20 of 21
Inositol 1,4,5-Trisphosphate Receptors in Hypertension.
(
Frontiers Media
, 2018 , Article Review)
Chronic hypertension remains a major cause of global mortality and morbidity. It is a complex disease that is the clinical manifestation of multiple genetic, environmental, nutritional, hormonal, and aging-related disorders. ...
CD44 mediates stem cell mobilization to damaged lung via its novel transcriptional targets, Cortactin and Survivin
(
Ivyspring International Publisher
, 2020 , Article)
Beyond their role in bone and lung homeostasis, mesenchymal stem cells (MSCs) are becoming popular in cell therapy. Various insults may disrupt the repair mechanisms involving MSCs. One such insult is smoking, which is a ...
Haematococcus pluvialis Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer Cells
(
Frontiers Media S.A.
, 2022 , Article)
Breast cancer (BC) is the most common malignant cancer in females worldwide. Drug resistance, toxicity, and the failure of current therapies to completely cure BC has challenged conventional medicine. Consequently, ...
Nox2 activity is required in obesity-mediated alteration of bone remodeling
(
Hindawi Limited
, 2018 , Article)
Despite increasing evidence suggesting a role for NADPH oxidases (Nox) in bone pathophysiology, whether Nox enzymes contribute to obesity-mediated bone remodeling remains to be clearly elucidated. Nox2 is one of the ...
SIRT1, a novel transcriptional downstream target of CD44, linking its deacetylase activity to tumor cell invasion/metastasis
(
Frontiers Media S.A.
, 2022 , Short Survey)
Our tetracycline-off-inducible CD44 expression system previously established in mouse model, revealed that activation of CD44 with its major ligand hyaluronan (HA) promoted breast cancer (BC) metastasis to the liver. To ...
PCF11, a Novel CD44-Downstream Transcriptional Target, Linking Its 3'-End Polyadenylation Function to Tumor Cell Metastasis
(
Frontiers Media S.A.
, 2022 , Article Review)
Breast Cancer (BC) is the most common and the major health issue in women worldwide. Metastasis, a multistep process, is the worst aspect of cancer and tumor cell invasion is the defining step. Tumor cell invasion requires ...
KYNU, a novel potential target that underpins CD44-promoted breast tumour cell invasion
(
Blackwell Publishing Inc.
, 2021 , Article Review)
Using a validated tetracycline-off-inducible CD44 expression system in mouse model, we have previously demonstrated that the hyaluronan (HA) receptor CD44 promotes breast cancer (BC) metastasis to the liver. To unravel the ...
The power of phytochemicals combination in cancer chemoprevention
(
Ivyspring International Publisher
, 2020 , Article Review)
Conventional therapies for cancer treatment have posed many challenges, including toxicity, multidrug resistance and economic expenses. In contrast, complementary alternative medicine (CAM), employing phytochemicals have ...
Antibody-Dependent Enhancement (ADE) and the role of complement system in disease pathogenesis
(
Elsevier Ltd
, 2022 , Article Review)
Antibody-dependent enhancement (ADE) has been associated with severe disease outcomes in several viral infections, including respiratory infections. In vitro and in vivo studies showed that antibody-response to SARS-CoV ...
Docosahexaenoic Acid, a Key Compound for Enhancing Sensitization to Drug in Doxorubicin-Resistant MCF-7 Cell Line.
(
MDPI
, 2023 , Article)
Drug resistance is a well-known and significant obstacle in the battle against cancer, rendering chemotherapy treatments often ineffective. To improve the effectiveness of chemotherapy, researchers are exploring the use ...