Browsing College of Medicine by Author "L. Calver, Brian"
Now showing items 1-4 of 4
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The Arrhythmogenic E105A CAM Mutation Dysregulates Normal Cardiac Function in Zebrafish by Altering CAM-Ca2+ and CAM-RyR2 Interactions
Nomikos, Michail; I. Da’as, Sahar; Thanassoulas, Angelos; Salem, Rola; L. Calver, Brian; Saleh, Alaaeldin; Al-Maraghi, Ali; K. Nasrallah, Gheyath; Safieh-Garabedian, Bared; Toft, Egon; Nounesis, George; Lai, F. Anthony... more authors ... less authors ( Elsevier , 2019 , Article)Calmodulin (CaM) is a multifunctional calcium (Ca2+)-binding messenger that directly interacts with the cardiac ryanodine receptor 2 (RyR2), a large transmembrane Ca2+ channel that mediates Ca2+ release from the sarcoplasmic ... -
Calmodulin Interacts and Regulates Enzyme Activity of the Mammalian Sperm Phospholipase C
Nomikos, Michail; Thanassoulas, Angelos; L. Calver, Brian; Theodoridou, Maria; Buntwal, Luke; Sideratou, Zili; Nounesis, George; Lai, F. Anthony... more authors ... less authors ( Elsevier , 2017 , Article)Sperm-specific Phospholipase C zeta (PLCζ) is widely considered to be the sole, physiological stimulus responsible for the generation of Ca2+ oscillations that induce egg activation and early embryo development during ... -
Calmodulin Mutations Associated with Congenital Cardiac Disease Display Novel Biophysical and Biochemical Characteristics
Nomikos, Michail; Thanassoulas, Angelos; L. Calver, Brian; Beck, Konrad; Vassilakopoulou, Vyronia; Buntwal, Luke; Konotgianni, Iris; Smith, Adrian; Safieh-Garabedian, Bared; Livaniou, Evangelia; Steen Toft, Egon; Nounesis, George... more authors ... less authors ( Elsevier , 2018 , Article)Calmodulin (CaM) is a cytoplasmic multifunctional calcium (Ca2+)-binding messenger that interacts with the cardiac ryanodine receptor (RyR2), a large transmembrane Ca2+ channel that mediates Ca2+ release from the sarcoplasmic ... -
Defective Interaction of Cam with RyR2 Cam-Binding Pocket Might Contribute to Arrhythmogenic Cardiac Disease
Nomikos, Michail; Thanassoulas, Angelos; Vassilakopoulou, Vyronia; L. Calver, Brian; Livaniou, Evangelia; Safieh-Garabedian, Bared; Toft, Egon; Nounesis, George; Lai, F. Anthony... more authors ... less authors ( Elsevier , 2020 , Article)Ryanodine receptor 2 (RyR2) is a large transmembrane calcium (Ca2+) release channel that mediates Ca2 release from the sarcoplasmic reticulum to activate cardiac muscle contraction. Calmodulin (CaM) regulation of RyR2 is ...