Search
Now showing items 21-30 of 166
TERT gene fusions characterize a subset of metastatic Leydig cell tumors
(
Elsevier
, 2021 , Article)
Objective: Metastatic Leydig cell tumors (LCT) are rare, difficult to treat malignancies without known underlying molecular-genetic events. An index case of metastatic LCT showed an LDLR-TERT gene fusion upon routine genetic ...
DEFECTIVE NATURAL KILLER CELLS IN MELANOMA: ROLE OF NKG2D IN THE PATHOGENESIS AND IMMUNOTHERAPY
(
Begell House
, 2021 , Article)
Melanoma is the most aggressive and deadliest form of skin cancer, and its prognosis is very poor. While the early detection is responsive to many treatments, metastatic melanoma is refractory to most of them. In the USA, ...
Outcomes of hyperglycaemia in pregnancy in Africa: Systematic review study protocol
(
BMJ Publishing Group
, 2021 , Article)
Introduction The prevalence of diabetes mellitus globally has increased considerably over the past decades with a resultant increase in the incidence of diabetes-complicated pregnancies. Hyperglycaemia in pregnancy is the ...
Identification of Co-Deregulated Genes in Urinary Bladder Cancer Using High-Throughput Methodologies
(
MDPI
, 2021 , Article)
Urinary bladder cancer (UBC) is the second most common urogenital solid tumor and the eleventh in the rank among all types of solid tumors. Although several oncogenes and tumor suppressors are known to be implicated in the ...
The store-operated Ca entry complex comprises a small cluster of STIM1 associated with one Orai1 channel.
(
National Academy of Sciences
, 2021 , Article)
Increases in cytosolic Ca concentration regulate diverse cellular activities and are usually evoked by opening of Ca channels in intracellular Ca stores and the plasma membrane (PM). For the many signals that evoke formation ...
Exploring the effect of image enhancement techniques on COVID-19 detection using chest X-ray images
(
Elsevier
, 2021 , Article)
Computer-aided diagnosis for the reliable and fast detection of coronavirus disease (COVID-19) has become a necessity to prevent the spread of the virus during the pandemic to ease the burden on the healthcare system. Chest ...
Homozygous mutation in MCM7 causes autosomal recessive primary microcephaly and intellectual disability
(
BMJ Publishing Group
, 2021 , Article)
Minichromosomal maintenance (MCM) complex components 2, 4, 5 and 6 have been linked to human disease with phenotypes including microcephaly and intellectual disability. The MCM complex has DNA helicase activity and is ...
High-risk human papillomaviruses and Epstein-Barr virus in breast cancer in Lebanese women and their association with tumor grade: a molecular and tissue microarray study.
(
BMC
, 2021 , Article)
High-risk human papillomaviruses (HPVs) are present and can cooperate with Epstein-Barr virus (EBV) to initiate and/or enhance the progression of several types of human carcinomas including cervical as well as head and ...
The Role of Pathology in the Era of Personalized (Precision) Medicine: A Brief Review.
(
NLM (Medline)
, 2021 , Article)
This review provides a brief overview of the state-of-the-art molecular pathology approaches emphasizing the increasingly important pathology role in clinical precision cancer medicine. Recent advances in molecular biology ...