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Metal-based nanoparticles: Promising tools for the management of cardiovascular diseases
(
Elsevier
, 2021 , Article)
Cardiovascular disease (CVD) is the leading cause of death worldwide. A search for more effective treatments of CVD is increasingly needed. Major advances in nanotechnology opened new avenues in CVD therapeutics. Owing to ...
Detection of Antinuclear Antibodies Targeting Intracellular Signal Transduction, Metabolism, Apoptotic Processes and Cell Death in Critical COVID-19 Patients
(
Universita Cattolica del Sacro Cuore
, 2022 , Article)
Background and Objectives: The heterogeneity of the coronavirus disease of 2019 (COVID-19) lies within its diverse symptoms and severity, ranging from mild to lethal. Acute respiratory distress syndrome (ARDS) is a leading ...
Modulation of Neuro-Inflammatory Signals in Microglia by Plasma Prekallikrein and Neuronal Cell Debris
(
Frontiers Media
, 2021 , Article)
Microglia, the resident phagocytes of the central nervous system and one of the key modulators of the innate immune system, have been shown to play a major role in brain insults. Upon activation in response to neuroinflammation, ...
The Effects of Statin Treatment on Serum Ferritin Levels: A Systematic Review and Meta-Analysis
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2022 , Article)
Background: Statins are the most widely used drugs for decreasing elevated serum LDL-cholesterol (LDL-C) and thus for the prevention of atherosclerotic cardiovascular disease (ASCVD), but they have also some pleiotropic ...
Beta-caryophyllene exhibits anti-proliferative effects through apoptosis induction and cell cycle modulation in multiple myeloma cells
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2021 , Article)
Cannabinoid receptors, which are widely distributed in the body, have been considered as possible pharmacological targets for the management of several tumors. Cannabinoid type 2 receptors (CB2Rs) belong to the G protein-coupled ...
Perirenal Adipose Tissue Inflammation: Novel Insights Linking Metabolic Dysfunction to Renal Diseases
(
Frontiers Media S.A.
, 2021 , Article)
A healthy adipose tissue (AT) is indispensable to human wellbeing. Among other roles, it contributes to energy homeostasis and provides insulation for internal organs. Adipocytes were previously thought to be a passive ...
Proatherogenic sialidases and desialylated lipoproteins: 35 years of research and current state from bench to bedside
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2021 , Article)
This review summarizes the main achievements in basic and clinical research of atheroscle-rosis. Focusing on desialylation as the first and the most important reaction of proatherogenic pathological cascade, we speak of ...
Pharmacological and antioxidant activities of rhus coriaria l. (sumac)
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2021 , Article)
Rhus coriaria L. (Anacardiaceae), commonly known as sumac, is a commonly used spice, condiment, and flavoring agent, especially in the Mediterranean region. Owing to its bountiful beneficial values, sumac has been used in ...
Adipose tissue immunomodulation: A novel therapeutic approach in cardiovascular and metabolic diseases
(
Frontiers Media
, 2020 , Article)
Adipose tissue is a critical regulator of systemic metabolism and bodily homeostasis as it secretes a myriad of adipokines, including inflammatory and anti-inflammatory cytokines. As the main storage pool of lipids, ...
Recent advances in nanotherapeutics for multiple myeloma
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2020 , Article)
Anticancer therapies cannot be included in a one-size-fits-all scenario; it is imperative to adapt therapies to the tumor molecular profile and most importantly to develop target-specific therapeutics. Nanotherapeutics can ...