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Now showing items 31-40 of 149
Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function
(
Nature Research
, 2023 , Article)
Voltage-gated sodium (NaV) channels are critical regulators of neuronal excitability and are targeted by many toxins that directly interact with the pore-forming α subunit, typically via extracellular loops of the ...
ApoM binds endotoxin contributing to neutralization and clearance by High Density Lipoprotein.
(
Elsevier
, 2023 , Article)
HDL possesses anti-inflammatory properties, however, the exact mechanism is not fully understood. Endotoxin is a potent inducers of TLR4 signaling, leading to inflammatory mediators' release. It has been estimated that ...
Sickness absenteeism among primary health care workers in Qatar before and during the COVID-19 pandemic
(
BioMed Central Ltd
, 2023 , Article)
Objectives: To explore the patterns, trends, nature, and extent of changes in sickness absence among health care workers (HCWs) at the Primary Health Care Corporation (PHCC) in Qatar-during the COVID-19 pandemic compared ...
Treatment with decitabine induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer: potential for combined chemoimmunotherapy
(
BioMed Central Ltd
, 2023 , Article)
Background: The mechanism of tumor immune escape and progression in colorectal cancer (CRC) is widely investigated in-vitro to help understand and identify agents that might play a crucial role in response to treatment and ...
Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
(
MDPI
, 2023 , Article)
Cancer is the second most life-threatening disease and has become a global health and economic problem worldwide. Due to the multifactorial nature of cancer, its pathophysiology is not completely understood so far, which ...
The Association Between Inflammatory Bowel Disease and Exposure to Tobacco Smoking: A Case-Control Study in Qatar
(
Dove Medical Press
, 2023 , Article)
Objective: This research investigated the association between childhood and adulthood tobacco smoking exposure with ulcerative colitis (UC) and Crohn’s disease (CD) in Qatar. Study Design and Setting: In this case-control ...
Fetal ECG extraction from maternal ECG using deeply supervised LinkNet++ model
(
Elsevier
, 2023 , Article)
Fetal heart monitoring and early disease detection using non-invasive fetal electrocardiograms (fECG) can help substantially to reduce infant death through improved diagnosis of Coronary Heart Disease (CHD) in the fetus. ...
Applications of Artificial Intelligence in Thalassemia: A Comprehensive Review
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2023 , Article)
Thalassemia is an autosomal recessive genetic disorder that affects the beta or alpha subunits of the hemoglobin structure. Thalassemia is classified as a hypochromic microcytic anemia and a definitive diagnosis of thalassemia ...
Clinical Phenotypes of PCOS: a Cross-Sectional Study
(
Springer
, 2023 , Article)
This cross-sectional study examines the Doi-Alshoumer PCOS clinical phenotype classification in relation to measured clinical and biochemical characteristics of women with polycystic ovary syndrome (PCOS). Two cohorts of ...
Blood Proteomics Analysis Reveals Potential Biomarkers and Convergent Dysregulated Pathways in Autism Spectrum Disorder: A Pilot Study
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2023 , Article)
Autism spectrum disorder (ASD) is an umbrella term that encompasses several disabling neurodevelopmental conditions. These conditions are characterized by impaired manifestation in social and communication skills with ...