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Metformin is comparable to insulin for pharmacotherapy in gestational diabetes mellitus: A network meta-analysis evaluating 6046 women.
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Elsevier
, 2021 , Article)
The comparative efficacy of gestational diabetes (GDM) treatments lack conclusive evidence for choice of first-line treatment. The aim of this study was to compare the efficacy of metformin and glibenclamide to insulin ...
Methodological issues of systematic reviews and meta-analyses in the field of sleep medicine: A meta-epidemiological study
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Elsevier
, 2021 , Article)
An increasing number of systematic reviews and meta-analyses (SRMAs) have been published in the field of sleep medicine. We evaluated the methodological issues of these SRMAs. A protocol was developed in advance. Three ...
Many meta-analyses of rare events in the Cochrane Database of Systematic Reviews were underpowered
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Elsevier
, 2021 , Article)
Background and ObjectiveMeta-analysis is a statistical method with the ability to increase the power for statistical inference, while it may still face the problem of being underpowered. In this study, we investigated the ...
Quality versus Risk-of-Bias assessment in clinical research
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Elsevier
, 2021 , Article)
Assessment of internal validity safeguards implemented by researchers has been used to examine the potential reliability of evidence generated within a study. These safeguards protect against systematic error, and such an ...
Utilization of the evidence from studies with no events in meta-analyses of adverse events: an empirical investigation
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Springer
, 2021 , Article)
Zero-events studies frequently occur in systematic reviews of adverse events, which consist of an important source of evidence. We aimed to examine how evidence of zero-events studies was utilized in the meta-analyses of ...
The odds ratio is “portable” but not the relative risk: Time to do away with the log link in binomial regression
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Elsevier
, 2021 , Article)
Objectives: In a recent paper we suggest that the relative risk (RR) be replaced with the odds ratio (OR) as the effect measure of choice in clinical epidemiology. In response, Chu, and colleagues raise several points that ...
Rapid evidence synthesis approach for limits on the search date: how rapid could it be?
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John Wiley and Sons
, 2021 , Article)
Rapid reviews have been widely employed to support timely decision-making, and limiting the search date is the most popular approach in published rapid reviews. We assessed the accuracy and workload of search date limits ...
Empirical Comparisons of 12 Meta-analysis Methods for Synthesizing Proportions of Binary Outcomes
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Springer
, 2021 , Article)
Background: Meta-analysis is increasingly used to synthesize proportions (e.g., disease prevalence). It can be implemented with widely used two-step methods or one-step methods, such as generalized linear mixed models ...
Synthesis of evidence from zero-events studies: A comparison of one-stage framework methods
(
John Wiley & Sons, Ltd
, 2021 , Article)
In evidence synthesis, dealing with zero-events studies is an important and complicated task that has generated broad discussion. Numerous methods provide valid solutions to synthesizing data from studies with zero-events, ...
Methodological assessment of systematic reviews and meta-analyses on COVID-19: A meta-epidemiological study
(
Wiley
, 2021 , Article)
Rationale, aims, and objectives: COVID-19 has caused an ongoing public health crisis. Many systematic reviews and meta-analyses have been performed to synthesize evidence for better understanding this new disease. However, ...