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SARS-CoV-2 Infection and Smoking: What is the association? A brief review
(
Elsevier
, 2021 , Article)
Susceptibility to severe illness from COVID-19 is anticipated to be associated with cigarette smoking as it aggravates the risk of cardiovascular and respiratory illness, including infections. This is particularly important ...
The MethodologicAl STandards for Epidemiological Research (MASTER) scale demonstrated a unified framework for bias assessment
(
Elsevier
, 2021 , Article)
Objective: This paper presents a unified framework for assessment of the methodological quality of analytic study designs. Study Design and Setting: A systematic review of 393 methodological quality assessment tools that ...
A proposed framework to guide evidence synthesis practice for meta-analysis with zero-events studies
(
Elsevier
, 2021 , Article)
ObjectiveIn evidence synthesis practice, researchers often face the problem of how to deal with zero-events. Inappropriately dealing with zero-events studies may lead to research waste and mislead healthcare practice. We ...
Abnormal brain structure and behavior in MyD88-deficient mice.
(
Elsevier
, 2021 , Article)
While the original protein Toll in Drosophila melanogaster regulates both host defense and morphogenesis, the role of its ortholog Toll-like receptors (TLRs), the interleukin 1 receptor (IL-1R) family, and the associated ...
Molecular correlates of immune cytolytic subgroups in colorectal cancer by integrated genomics analysis
(
Oxford University Press
, 2021 , Article)
Although immune checkpoint inhibition (ICI) has shown promising results in metastatic dMMR/MSI-H colorectal cancer (CRC), the majority of pMMR/MSS patients do not respond to such therapies. To systematically evaluate the ...
TERT gene fusions characterize a subset of metastatic Leydig cell tumors
(
Elsevier
, 2021 , Article)
Objective: Metastatic Leydig cell tumors (LCT) are rare, difficult to treat malignancies without known underlying molecular-genetic events. An index case of metastatic LCT showed an LDLR-TERT gene fusion upon routine genetic ...
DEFECTIVE NATURAL KILLER CELLS IN MELANOMA: ROLE OF NKG2D IN THE PATHOGENESIS AND IMMUNOTHERAPY
(
Begell House
, 2021 , Article)
Melanoma is the most aggressive and deadliest form of skin cancer, and its prognosis is very poor. While the early detection is responsive to many treatments, metastatic melanoma is refractory to most of them. In the USA, ...
Outcomes of hyperglycaemia in pregnancy in Africa: Systematic review study protocol
(
BMJ Publishing Group
, 2021 , Article)
Introduction The prevalence of diabetes mellitus globally has increased considerably over the past decades with a resultant increase in the incidence of diabetes-complicated pregnancies. Hyperglycaemia in pregnancy is the ...
Identification of Co-Deregulated Genes in Urinary Bladder Cancer Using High-Throughput Methodologies
(
MDPI
, 2021 , Article)
Urinary bladder cancer (UBC) is the second most common urogenital solid tumor and the eleventh in the rank among all types of solid tumors. Although several oncogenes and tumor suppressors are known to be implicated in the ...
The store-operated Ca entry complex comprises a small cluster of STIM1 associated with one Orai1 channel.
(
National Academy of Sciences
, 2021 , Article)
Increases in cytosolic Ca concentration regulate diverse cellular activities and are usually evoked by opening of Ca channels in intracellular Ca stores and the plasma membrane (PM). For the many signals that evoke formation ...