Browsing College of Pharmacy by Author "Rachid, Ousama"
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A protocol to investigate the stability of 0.9% sodium chloride IV fluid bags in the prehospital setting of Qatar
Makhlouf, Ahmed; Alinier, Guillaume; Kerkeni, Habib; Al Shaikh, Loua; Rachid, Ousama ( Hamad bin Khalifa University Press (HBKU Press) , 2022 , Article)Background: 0.9% sodium chloride (NaCl) fluid bags are commonly stored in ambulances. Despite that the ambulances normally use air-conditioning during operational shifts, NaCl bags are exposed to deviations from the ... -
A systematic review of stability of medicines used in emergency medical service settings
Rachid, Ousama; Obasi, Joy; Mohamed Ibrahim, MohamedIzham; Diab, Mohammad; Al-Moslih, Ayad; Makhlouf, Ahmed; Alinier, Guillaume... more authors ... less authors ( Hamad bin Khalifa University Press (HBKU Press) , 2020 , Article)Background: Temperature, among several environment conditions like humidity, is known to impact medicine stability 1,2 . In emergency medical service (EMS) settings, it is often challenging to control these conditions. In ... -
Can we use normal saline stored under stress conditions? A simulated prehospital emergency medical setting
Rachid, Ousama; Akkbik, Mohammed; Alkilany, Alaaldin M.; Makhlouf, Ahmed; Al Shaikh, Loua; Alinier, Guillaume... more authors ... less authors ( Elsevier Ltd , 2023 , Article)Background: Data on stability and suitability to use normal saline stored under stress conditions in ambulances is lacking. Objective: We aimed to study the impact of exposure to extreme temperature variations on normal ... -
Comprehensive evaluation of the pharmacological and toxicological effects of γ-valerolactone as compared to γ-hydroxybutyric acid: Insights from in vivo and in silico models
Arfè, Raffaella; Bilel, Sabrine; Tirri, Micaela; Corli, Giorgia; Bergamin, Eva; Serpelloni, Giovanni; Bassi, Marta; Borsari, Martina; Boccuto, Federica; Bernardi, Tatiana; Caruso, Lorenzo; Alkilany, Alaaldin M.; Rachid, Ousama; Botrè, Francesco; De-Giorgio, Fabio; Marti, Matteo... more authors ... less authors ( Elsevier , 2023 , Article)Γ-valerolactone (GVL), marketed online as “Tranquilli-G” and “excellent Valium”, is used as a legal substitute for γ-hydroxybutyric acid (GHB); however, until now, GVL has only been connected to one Drug-Facilitated Sexual ... -
Creation of an inventory of quality markers used to evaluate pharmacokinetic literature: A systematic review
Soliman, Alaa Bahaa Eldeen; Pawluk, Shane Ashley; Wilby, Kyle John; Rachid, Ousama ( Wiley , 2021 , Article Review)What is known and objective: Robust critical appraisal tools for clinical pharmacokinetic studies are limited. Before development of such a tool is possible, quality markers (items deemed important for credibility of study ... -
CTLA4-Ig (abatacept): a promising investigational drug for use in type 1 diabetes.
Rachid, Ousama; Osman, Aisha; Abdi, Reza; Haik, Yousef ( Taylor & Francis , 2020 , Article Review)Type 1 diabetes (T1D) is an autoimmune disease that results from the destruction of insulin-producing beta cells in the pancreas; it leads to the under or nonproduction of insulin. T1D is associated with numerous ... -
Development of a college-level assessment framework in line with international accreditation standards: A Middle Eastern perspective.
Wilby, Kyle John; Zolezzi, Monica; Rachid, Ousama; El-Kadi, Ayman ( Elsevier , 2017 , Article)Accreditation of international pharmacy programs by North American and European accrediting bodies is becoming increasingly popular. Practices regarding assessment and evaluation are especially highlighted in accreditation ... -
Development of a protocol to investigate the stability of drugs used by Qatar's National Ambulance Service in rapid response vehicles
Rachid, Ousama; Makhlouf, Ahmed; Abdulselam, Meral; Benammar, Sarra; Omer, Elaf; AlDakhakhny, Salma; Abolward, Alzahraa; Kerkeni, Habib; Al Shaikh, Loua; Alinier, Guillaume... more authors ... less authors ( Hamad bin Khalifa University Press (HBKU Press) , 2022 , Article)Background: Paramedics need a range of medications that are stored in bags for easy transportation to the patient's side and are exposed to temperature variations, especially in a hot country like Qatar 1 . The thermal ... -
Emerging innate biological properties of nano-drug delivery systems: A focus on PAMAM dendrimers and their clinical potential
Kheraldine, Hadeel; Rachid, Ousama; M Habib, Abdella; Al Moustafa, Ala-Eddin; F. Benter, Ibrahim ( Elsevier , 2021 , Article)Drug delivery systems or vectors are usually needed to improve the bioavailability and effectiveness of a drug through improving its pharmacokinetics/pharmacodynamics at an organ, tissue or cellular level. However, emerging ... -
Epinephrine in anaphylaxis: Preclinical study of pharmacokinetics after sublingual administration of taste-masked tablets for potential pediatric use
Rachid, Ousama; Rawas-Qalaji, Mutasem; Simons, Keith J. ( MDPI AG , 2018 , Article)Epinephrine is a life-saving treatment in anaphylaxis. In community settings, a first-aid dose of epinephrine is injected from an auto-injector (EAI). Needle phobia highly contributes to EAI underuse, leading to ... -
In Vivo Evaluation of Taste-Masked Fast-Disintegrating Sublingual Tablets of Epinephrine Microcrystals
Rachid, Ousama; Simons, Keith J.; Rawas-Qalaji, Mutasem ( Springer New York LLC , 2018 , Article)n community settings, IM injection of 0.3 mg epinephrine (Epi) using an auto-injector is the drug of choice for treatment of anaphylaxis. Previously, a taste-masking (TM) formulation of fast-disintegrating sublingual tablets ... -
Intravenous fluids in hot pre-hospital environments: Thermal and physical stability of normal saline after exposure to simulated stress conditions
Rachid, Ousama; Akkbik, Mohammed; Makhlouf, Ahmed; Moslih, Ayad; Al Shaikh, Loua; Alinier, Guillaume... more authors ... less authors ( Hamad bin Khalifa University Press (HBKU Press) , 2022 , Article)Background: Normal saline 0.9 % (NS) is the most widespread crystalloid used as a life-saving intravenous (IV) fluid. 1 NS contains sodium and chloride in equal concentrations and is subject to thermal stress conditions ... -
Monitoring temperature and humidity in ambulance service rapid-response vehicles and paramedics medication bags: A pilot study
Rachid, Ousama; Makhlouf, Ahmed; Kerkeni, Habib; Alinier, Guillaume ( Hamad bin Khalifa University Press (HBKU Press) , 2022 , Article)Background: In the pre-hospital context, paramedics carry medications in multi-compartment medication bags. However, these medications are occasionally subjected to temperature and humidity variations as they are being ... -
Naked Poly(amidoamine) Dendrimer Nanoparticles Exhibit Intrinsic Embryotoxicity During the Early Stages of Normal Development.
Kheraldine, Hadeel; Gupta, Ishita; Alhussain, Hashim; Jabeen, Ayesha; Akhtar, Saghir; Al Moustafa, Ala-Eddin; Rachid, Ousama... more authors ... less authors ( American Science Publishers ASP , 2020 , Article)To investigate the impact of poly(amidoamine) dendrimers (PAMAMs) in the embryo, we explored the outcome of different generations (G₄ and G) on the early stages of embryogenesis using the chicken embryo as a model. We also ... -
Pharmaceutical Characterization of MyoNovin, a Novel Skeletal Muscle Regenerator: in silico, in vitro and in vivo Studies.
Alrushaid, Samaa; Davies, Neal M; Anderson, Judy E; Le, Tyson; Yáñez, Jaime A; Maayah, Zaid H; El-Kadi, Ayman O S; Rachid, Ousama; Sayre, Casey L; Löbenberg, Raimar; Burczynski, Frank J... more authors ... less authors ( Canadian Society for Pharmaceutical Sciences , 2018 , Article)MyoNovin is a novel skeletal muscle-regenerating compound developed through synthesis of two nitro groups onto a guaifenesin backbone to deliver nitric oxide to skeletal muscle with a potential to treat muscle atrophy. The ... -
Pharmaco-toxicological effects of the novel tryptamine hallucinogen 5-MeO-MiPT on motor, sensorimotor, physiological, and cardiorespiratory parameters in mice—from a human poisoning case to the preclinical evidence
Bassi, Marta; Bilel, Sabrine; Tirri, Micaela; Corli, Giorgia; Di Rosa, Fabiana; Gregori, Adolfo; Alkilany, Alaaldin M.; Rachid, Ousama; Roda, Elisa; Zauli, Giorgio; Locatelli, Carlo Alessandro; Marti, Matteo... more authors ... less authors ( Springer Nature , 2024 , Article)Rationale: The 5-methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT, known online as “Moxy”) is a new psychedelic tryptamine first identified on Italian national territory in 2014. Its hallucinogen effects are broadly ... -
PLGA-Gold Nanocomposite: Preparation and Biomedical Applications
Alkilany, Alaaldin M.; Rachid, Ousama; Alkawareek, Mahmoud Y.; Billa, Nashiru; Daou, Anis; Murphy, Catherine J.... more authors ... less authors ( MDPI , 2022 , Article)A composite system consisting of both organic and inorganic nanoparticles is an approach to prepare a new material exhibiting “the best of both worlds”. In this review, we highlight the recent advances in the preparation ... -
Rivaroxaban Pharmacokinetics in Obese Subjects: A Systematic Review
Alalawneh, Majdoleen; Awaisu, Ahmed; Rachid, Ousama ( Springer Nature , 2022 , Article)Venous thromboembolism (VTE) is a leading cause of morbidity and mortality globally. The direct oral anticoagulants, including rivaroxaban, are relatively novel therapeutic options in the treatment and prevention of VTE. ... -
Substantial cell apoptosis provoked by naked PAMAM dendrimers in HER2-positive human breast cancer via JNK and ERK1/ERK2 signalling pathways
Hadeel, Kheraldine; Gupta, Ishita; Alhussain, Hashim; Jabeen, Aayesha; Cyprian, Farhan S.; Akhtar, Saghir; Al Moustafa, Ala-Eddin; Rachid, Ousama... more authors ... less authors ( Elsevier , 2021 , Article)HER2-positive breast cancer is one of its most challenging subtypes, forming around 15–25% of the total cases. It is characterized by aggressive behavior and treatment resistance. On the other hand, poly (amidoamine) (PAMAM) ... -
The use of a modified Delphi technique to develop a critical appraisal tool for clinical pharmacokinetic studies.
Soliman, Alaa Bahaa Eldeen; Pawluk, Shane Ashley; Wilby, Kyle John; Rachid, Ousama ( Springer , 2022 , Article)Critical appraisal aids in assessing the quality of scientific literature, which is central to the practice of evidence-based medicine. Several tools and guidelines are available for critiquing and assessing the quality ...