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Metformin Attenuates Albumin-induced Alterations in Renal Tubular Cells In Vitro
(
Wiley Periodicals, Inc
, 2017 , Article)
Proteinuria (albuminuria) plays a crucial role in the etiology of chronic kidney disease (CKD) via alteration of multiple signaling pathways and cellular process in renal cells. The objectives of this study are to investigate ...
Structure–activity relationship of piperine and its synthetic amide analogs for therapeutic potential to prevent experimentally induced ER stress in vitro
(
Springer Netherlands
, 2017 , Article)
Endoplasmic reticulum (ER) is the key organelle involved in protein folding and maturation. Emerging studies implicate the role of ER stress in the development of chronic kidney disease. Thus, there is an urgent need for ...
Nephroprotective Effects of Metformin in Diabetic Nephropathy
(
Wiley
, 2017 , Article)
Metformin, a well-known anti-diabetic agent, is very effective in lowering blood glucose in patients with type 2 diabetes with minimal side-effects. Metformin is also being recommended in the treatment of obesity and ...
Aldose Reductase as a Drug Target for Treatment of Diabetic Nephropathy: Promises and Challenges.
(
Bentham Science Publishers
, 2017 , Article)
Diabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes mellitus and the leading cause of end stage renal disease. One of the key pathways activated in DN is the polyol pathway, in which ...
Obesity-induced changes in kidney mitochondria and endoplasmic reticulum in the presence or absence of leptin
(
American Physiological Society
, 2015 , Article)
We investigated obesity-induced changes in kidney lipid accumulation, mitochondrial function, and endoplasmic reticulum (ER) stress in the absence of hypertension, and the potential role of leptin in modulating these ...
Corrigendum: Renoprotective Effects of Aldose Reductase Inhibitor Epalrestat against High Glucose-Induced Cellular Injury (BioMed Research International (2017) 2017 (5903105) DOI: 10.1155/2017/5903105)
(
Hindawi Limited
, 2019 , Other)
Following publication of the article, Renoprotective Effects of Aldose Reductase Inhibitor Epalrestat against High Glucose-Induced Cellular Injury, the authors were made aware that the effects of epalrestat on the high ...
The use of Socrative and Yammer online tools to promote interactive learning in pharmacy education
(
Elsevier Inc.
, 2019 , Article)
Background and purpose
Engagement of students in the didactic classroom setting restricts students’ time spent towards active learning, which in turn, adversely affects the retention of concepts taught through traditional ...
Role of methylglyoxal in diabetic cardiovascular and kidney diseases: Insights from basic science for application into clinical practice
(
Bentham Science Publishers
, 2018 , Other)
Background: The incidence and prevalence of diabetes mellitus are increasing globally at alarming rates. Cardiovascular and renal complications are the major cause of morbidity and mortality in patients with diabetes. ...