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Common and Rare Genetic Variants Associated With Alzheimer's Disease

المؤلفMarei, Hany E.
المؤلفAlthani, Asmaa
المؤلفSuhonen, Jaana
المؤلفEl Zowalaty, Mohamed E.
المؤلفAlbanna, Mohammad A.
المؤلفCenciarelli, Carlo
المؤلفWang, Tengfei
المؤلفCaceci, Thomas
تاريخ الإتاحة2016-07-20T11:08:01Z
تاريخ النشر2016-07-01
اسم المنشورJournal of Cellular Physiology
الاقتباسMarei, H. E., Althani, A., Suhonen, J., El Zowalaty, M. E., Albanna, M. A., Cenciarelli, C., Wang, T. and Caceci, T. (2016), Common and Rare Genetic Variants Associated With Alzheimer's Disease. J. Cell. Physiol., 231: 1432–1437. doi: 10.1002/jcp.25225
الرقم المعياري الدولي للكتاب0021-9541(print)
الرقم المعياري الدولي للكتاب1097-4652(online)
معرّف المصادر الموحدhttp://dx.doi.org/10.1002/jcp.25225
معرّف المصادر الموحدhttp://hdl.handle.net/10576/4684
الملخصAlzheimer's disease (AD) is one of the most devastating disorders. Despite the continuing increase of its incidence among aging populations, no effective cure has been developed mainly due to difficulties in early diagnosis of the disease before damaging of the brain, and the failure to explore its complex underlying molecular mechanisms. Recent technological advances in genome-wide association studies (GWAS) and high throughput next generation whole genome, and exome sequencing had deciphered many of AD-related loci, and discovered single nucleotide polymorphisms (SNPs) that are associated with altered AD molecular pathways. Highlighting altered molecular pathways linked to AD pathogenesis is crucial to identify novel diagnostic and therapeutic AD targets.
راعي المشروعBRC, QU
اللغةen
الناشرWILEY PERIODICALS, INC.
الموضوعGenetic varients
Alzheimer's disease
rare varients
common varients
العنوانCommon and Rare Genetic Variants Associated With Alzheimer's Disease
النوعArticle
الصفحات1432–1437
رقم العدد7
رقم المجلد231


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