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The Association between Serum LDL Cholesterol and Genetic Variation in Chromosomal Locus 1p13.3 among Coronary Artery Disease Patients
(
Hindawi
, 2015 , Article)
Background. Several polymorphisms of a locus on chromosome 1p13.3 have a significant effect on low-density lipoprotein cholesterol (LDL-C), atherosclerosis, and acute coronary syndrome (ACS). Methods. We aimed to investigate ...
Use of Germ-Free Animal Models in Microbiota-Related Research
(
The Korean Society for Microbiology and Biotechnology
, 2015 , Article)
The large intestine is a home for trillions of microbiota, which confer many benefits on the host, including production of vitamins, absorption of nutrients, pathogen displacement, and development of the immune system. For ...
The cardiovascular implication of single nucleotide polymorphisms of chromosome 9p21 locus among Arab population
(
Medknow Publications
, 2015 , Article)
Background: Based on several reports including genome-wide association studies, genetic variability has been linked with higher (nearly half) susceptibility toward coronary artery disease (CAD). We aimed to evaluate the ...
Editorial: State of art and science advances on nutrition and nutrigenetics in nutrition –related non-communicable diseases in Middle East
(
BioMed Central
, 2015 , Article)
(Not Applicable)
Krabbe Disease in the Arab World
(
IOS Press
, 2015 , Article)
The autosomal recessive inherited Krabbe disease (KD) is a devastating pediatric lysosomal storage disorder affecting white matter of the brain. It is caused by mutations in the gene coding for the lysosomal enzyme ...
A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase
(
American Society for Biochemistry and Molecular Biology
, 2015 , Article)
Retinal hyperpermeability and subsequent macular edema is a cardinal feature of early diabetic retinopathy (DR). Here, we investigated the role of bioactive lipid metabolites, in particular 12/15-lipoxygenase (LOX)-derived ...
Bioavailability and hypolipidemic effects of peanut skin polyphenols
(
Mary Ann Liebert, Inc.
, 2015 , Article)
Peanut skin is a rich source of polyphenols, such as proanthocyanidins. Peanut skin proanthocyanidins mainly
consist of a subgroup called procyanidins. Peanut-based procyanidins contain oligomers of both type A and type ...
Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids
(
Elsevier
, 2015 , Article)
We recently demonstrated that 12/15-lipoxygenase (LOX) derived metabolites, hydroxyeicosatetraenoic acids (HETEs), contribute to diabetic retinopathy (DR) via NADPH oxidase (NOX) and disruption of the balance in retinal ...
Editorial: Novel Targeted Therapy for Lung Cancer
(
OMICS International
, 2015 , Article)
Lung cancer accounts for about 27% of all cancer deaths and considered as the leading cause of cancer-associated death worldwide. Genotype-driven therapeutics is a standard of care for majority of subgroup of NSCLC patients ...
Propionic acidemia in the Arab World.
(
Elsevier
, 2015 , Article)
The autosomal recessive disease propionic acidemia (PA) is an inborn error of metabolism with highly variable clinical manifestations, caused by a deficiency of propionyl-CoA carboxylase (PCC) enzyme, due to mutations in ...