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The Association between Serum LDL Cholesterol and Genetic Variation in Chromosomal Locus 1p13.3 among Coronary Artery Disease Patients
(
Hindawi
, 2015 , Article)
Background. Several polymorphisms of a locus on chromosome 1p13.3 have a significant effect on low-density lipoprotein cholesterol (LDL-C), atherosclerosis, and acute coronary syndrome (ACS). Methods. We aimed to investigate ...
Sanguinarine Induces Apoptosis in Papillary Thyroid Cancer Cells via Generation of Reactive Oxygen Species.
(
MDPI
, 2020 , Article)
Sanguinarine (SNG), a natural compound with an array of pharmacological activities, has promising therapeutic potential against a number of pathological conditions, including malignancies. In the present study, we have ...
Immunomodulation Induced by Host Pathogen Interaction
(
Hindawi
, 2019 , Article)
Controlling and preventing infections require deep understanding of the complex interplay that occurs between the host and pathogen following infection. In essence, immunomodulation is any process leading to an immune ...
Systematic Review of the Respiratory Syncytial Virus (RSV) Prevalence, Genotype Distribution, and Seasonality in Children from the Middle East and North Africa (MENA) Region
(
MDPI
, 2020 , Article)
Respiratory syncytial virus (RSV) is one of the most common viruses to infect children worldwide and is the leading cause of lower respiratory tract illness (LRI) in infants. This study aimed to conduct a systematic review ...
Use of Germ-Free Animal Models in Microbiota-Related Research
(
The Korean Society for Microbiology and Biotechnology
, 2015 , Article)
The large intestine is a home for trillions of microbiota, which confer many benefits on the host, including production of vitamins, absorption of nutrients, pathogen displacement, and development of the immune system. For ...
Viruses and Autoimmunity: A Review on the Potential Interaction and Molecular Mechanisms.
(
MDPI
, 2019 , Article)
For a long time, viruses have been shown to modify the clinical picture of several autoimmune diseases, including type 1 diabetes (T1D), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren's syndrome ...
A Tailored, Bundle Care Intervention Strategy to Reduce Cardiac Mortality During the Hajj: A Population-Based, Before and After Study.
(
SAGE Publications
, 2019 , Article)
Hajj is the largest human gathering with over 2 million people. We evaluated the effect of bundle care intervention on mortality. A population-based, before and after study compared the effect of an intervention on mortality. ...
Bladder neoplasms and NF-κB: an unfathomed association.
(
Taylor & Francis
, 2020 , Article)
Bladder cancer is the second most common genitourinary tract cancer and is often recurrent and/or chemoresistant after tumor resection. Cigarette smoking, exposure to aromatic amines, and chronic infection/inflammation are ...
Molecular dynamics simulations to decipher the structural and functional consequences of pathogenic missense mutations in the galactosylceramidase (GALC) protein causing Krabbe's disease.
(
Taylor & Francis
, 2020 , Article)
Krabbe disease (KD), also known as globoid cell leukodystrophy disease, is an autosomal recessive lysosomal storage genetic disorder, which is caused by the deficiecncy of galactocerebrosidase (GALC) coding gene (). This ...
The cardiovascular implication of single nucleotide polymorphisms of chromosome 9p21 locus among Arab population
(
Medknow Publications
, 2015 , Article)
Background: Based on several reports including genome-wide association studies, genetic variability has been linked with higher (nearly half) susceptibility toward coronary artery disease (CAD). We aimed to evaluate the ...