Browsing Biomedical Sciences by Author "Al-Asmakh, Maha"
Now showing items 1-19 of 19
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AEO-7 surfactant is “super toxic” and induces severe cardiac, liver and locomotion damage in zebrafish embryos
Al-Asmakh, Maha; Majdalawieh, Amin F.; Abdullah, Aboubakr M.; Younes, Nadin; Da’as, Sahar I.; Radwan, A. Bahgat; Sliem, Mostafa H.; Ech-Cherif, Houria; Pintus, Gianfranco; Nasrallah, Gheyath K.... more authors ... less authors ( SpringerOpen , 2020 , Article)© 2020, The Author(s). Background: Fatty alcohol polyoxyethylene ether-7 (AEO-7), a non-ionic surfactant, has recently been receiving extensive attention from the ocean pipeline industry for its ability to inhibit corrosion. ... -
Bidirectional communication between the Aryl hydrocarbon Receptor (AhR) and the microbiome tunes host metabolism
Korecka, Agata; Dona, Anthony; Lahiri, Shawon; Tett, Adrian James; Al-Asmakh, Maha; Braniste, Viorica; D'Arienzo, Rossana; Abbaspour, Afrouz; Reichardt, Nicole; Fujii-Kuriyama, Yoshiaki; Rafter, Joseph; Narbad, Arjan; Holmes, Elaine; Nicholson, Jeremy; Arulampalam, Velmurugesan; Pettersson, Sven... more authors ... less authors ( Nature Publishing Group in partnership with Nanyang Technological University , 2016 , Article)The ligand-induced transcription factor, aryl hydrocarbon receptor (AhR) is known for its capacity to tune adaptive immunity and xenobiotic metabolism-biological properties subject to regulation by the indigenous microbiome. ... -
Biochemical and cellular basis of oxidative stress: Implications for disease onset
Aramouni, Karl; Assaf, Roland; Shaito, Abdullah; Fardoun, Manal; Al-Asmakh, Maha; Sahebkar, Amirhossein; Eid, Ali H.... more authors ... less authors ( Wiley , 2023 , Article Review)Cellular oxidation–reduction (redox) systems, which encompass pro- and antioxidant molecules, are integral components of a plethora of essential cellular processes. Any dysregulation of these systems can cause molecular ... -
Dysbiosis of the Salivary Microbiome is Associated with Hypertension and Correlated with Metabolic Syndrome Biomarkers
Sohail, Muhammad U; Hedin, Lars; Al-Asmakh, Maha ( Dovepress , 2021 , Article)Background: Hypertension (HT) is an idiopathic disease with severe complications and a high incidence of global mortality. Although the disease shares characteristic features with diabetes and obesity, the complex interplay ... -
Ecotoxicological assessment of Ti3C2Tx (MXene) using a zebrafish embryo model
Nasrallah, Gheyath; Al-Asmakh, Maha; Rasool, Kashif; Mahmoud, Khaled ( Royal Society of Chemistry , 2018 , Article)The recent application of 2D Ti3C2Tx (MXene) nanomaterials as adsorbents and membranes for water treatment as well as for biomedical applications is attracting a growing interest. However, the environmental impact of MXene ... -
The effect of surface-modified gold nanorods on the early stage of embryonic development and angiogenesis: Insight into the molecular pathways
Mahmoud, Nouf N.; Zakaria, Zain Zaki; Kheraldine, Hadeel; Gupta, Ishita; Vranic, Semir; Al-Asmakh, Maha; Moustafa, Ala Eddin Al... more authors ... less authors ( MDPI , 2021 , Article)Gold nanorods have been implicated in several biomedical applications. Herein, the effect of two surface-modified gold nanorods on the early stages of embryogenesis and angiogenesis was investigated using avian embryos at ... -
Effect of Water-Pipe Smoking on the Normal Development of Zebrafish
Zakaria, Zain Zaki; Aladwi, Shaima Ahmad; Benslimane, Fatiha; Al-Absi, Enas S.; Al-Shafai, Mashael; Yalcin, Huseyin C.; Khalil, Ashraf; Al Moustafa, Ala-Eddin; Al-Asmakh, Maha... more authors ... less authors ( MDPI , 2021 , Article)Background: Among all types of tobacco consumption,Water-Pipe Smoking (WPS) is the most widely used in the Middle East and second-most in several other countries. The effect of WPS on normal development is not yet fully ... -
The Effects of Gum Acacia on the Composition of the Gut Microbiome and Plasma Levels of Short-Chain Fatty Acids in a Rat Model of Chronic Kidney Disease
Al-Asmakh, Maha; Sohail, Muhammad Umar; Al-Jamal, Ola; Shoair, Banan Mosaad; Al-Baniali, Asmaa Yousef; Bouabidi, Salma; Nasr, Shahd; Bawadi, Hiba... more authors ... less authors ( Frontiers Media , 2020 , Article)Chronic kidney disease (CKD) may be fatal for its victims and is an important long-term public health problem. The complicated medical procedures and diet restrictions to which patients with CKD are subjected alter the gut ... -
The effects of oxygen concentration on in vitro output of prostaglandin E2 and interleukin-6 from human fetal membranes.
Al-Asmakh, Maha; Race, H; Tan, S; Sullivan, M.H.F. ( Oxford University Press , 2007 , Article)Labour at all gestational ages has clear biochemical parallels with an inflammatory response, typified by the increased output of prostaglandins (PGs) and cytokines within the pregnant uterus. The main sources are the fetal ... -
The impact of microbial composition on postprandial glycaemia and lipidaemia: A systematic review of current evidence
Wilson, Megan L.; Davies, Ian G.; Waraksa, Weronika; Khayyatzadeh, Sayyed S.; Al-Asmakh, Maha; Mazidi, Mohsen... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)Postprandial hyperglycaemia is associated with increased risk of cardiovascular disease. Recent studies highlight the role of the gut microbiome in influencing postprandial glycaemic (PPG) and lipidaemic (PPL) responses. ... -
Intermittent fasting favorably modulates adipokines and potentially attenuates atherosclerosis
Al Zein, Mohammad; Zein, Omar; Diab, Rawan; Dimachkie, Lina; Sahebkar, Amirhossein; Al-Asmakh, Maha; Kobeissy, Firas; Eid, Ali H.... more authors ... less authors ( Elsevier Inc. , 2023 , Article)Adipose tissue is now recognized as an endocrine organ that secretes bioactive molecules called adipokines. These biomolecules regulate key physiological functions, including insulin sensitivity, energy metabolism, appetite ... -
The Interplay Between Diet and the Epigenome in the Pathogenesis of Type-1 Diabetes
Kohil, Amira; Al-Asmakh, Maha; Al-Shafai, Mashael; Terranegra, Annalisa ( Frontiers , 2021 , Article Review)The autoimmune disease, Type 1 Diabetes Mellitus (T1DM), results in the destruction of pancreatic β-cells, and the International Diabetes Federation reports that its incidence is increasing worldwide. T1DM is a complex ... -
Maternal microbiota regulate glucocorticoids levels and placental development in mice
Al-Asmakh, Maha; Hedin, Lars; Pettersson, Sven ( bioscientifica , 2015 , Conference Proceedings)The gut microbiota contributes to postnatal development and maturation by influencing barrier functions of the intestinal wall, the development of the immune system, and the utilisation of nutrients. Recent studies have ... -
Microbiome profiling of rotavirus infected children suffering from acute gastroenteritis.
Sohail, Muhammad U; Al Khatib, Hebah A; Al Thani, Asmaa A; Al Ansari, Khalid; Yassine, Hadi M; Al-Asmakh, Maha... more authors ... less authors ( BMC , 2021 , Report)Rotavirus (RV) is a leading cause of pediatric diarrhea and mortality worldwide. The virus causes acute gastroenteritis characterized by moderate to severe vomiting, diarrhea, dehydration, and fever. Microbial dysbiosis ... -
The Microbiota and Gut-Related Disorders: Insights from Animal Models
Kamareddine, Layla; Najjar, Hoda; Abdulkader, Hadil; Al-Asmakh, Maha; Sohail, Muhammad Umar ( MDPI , 2020 , Article Review)Over the past decade, the scientific committee has called for broadening our horizons in understanding host–microbe interactions and infectious disease progression. Owing to the fact that the human gut harbors trillions ... -
“Safe” Chitosan Zinc Oxide Nanocomposite Has Minimal Organ-Specific Toxicity on Early Stages of Zebrafish Development
Younes, Nadin; Pintus, Gianfranco; Al-Asmakh, Maha; Rasool, Kashif; Younes, Salma; Calzolari, Simone; Mahmoud, Khaled; Nasrallah, Gheyath... more authors ... less authors ( American Chemical Society , 2019 , Article)Marine biofouling is considered one of the most challenging issues affecting maritime industries worldwide. In this regard, traditional biocides, being used to combat biofouling, have high toxicity toward the aquatic system. ... -
SARS-CoV-2 and immune-microbiome interactions: Lessons from respiratory viral infections
Farhan, Cyprian; Sohail, Muhammad Umar; Abdelhafez, Ibrahim; Salman, Salma; Attique, Zakria; Kamareddine, Layla; Al-Asmakh, Maha... more authors ... less authors ( Elsevier , 2021 , Article)By the beginning of 2020, infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had rapidly evolved into an emergent worldwide pandemic, an outbreak whose unprecedented consequences highlighted ... -
SARS-CoV-2 Infection and Smoking: What is the association? A brief review
Ishita, Gupta; Sohail, Muhammad Umar; Elzawawi, Khaled E.; Amarah, Ahmed H.; Vranic, Semir; Al-Asmakh, Maha; Moustafa, Ala-Eddin Al... more authors ... less authors ( Elsevier , 2021 , Article)Susceptibility to severe illness from COVID-19 is anticipated to be associated with cigarette smoking as it aggravates the risk of cardiovascular and respiratory illness, including infections. This is particularly important ... -
Toxicity evaluation of selected ionic liquid compounds on embryonic development of Zebrafish.
Younes, Nadin; Salem, Rola; Al-Asmakh, Maha; Altamash, Tausif; Pintus, Gianfranco; Khraisheh, Majeda; Nasrallah, Gheyath K... more authors ... less authors ( Elsevier , 2018 , Article)Hydrate formation in seafloor pipelines is considered an economic and flow assurance issue for the oil and gas industries. Ionic liquids (ILs) have been recently used as potential hydrate inhibitors. Although branded as ...