تصفح Biomedical Sciences حسب المؤلف "Al-Muftah, Wadha"
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A population study of clinically actionable genetic variation affecting drug response from the Middle East
Jithesh, Puthen Veettil; Abuhaliqa, Mohammed; Syed, Najeeb; Ahmed, Ikhlak; El Anbari, Mohammed; Bastaki, Kholoud; Sherif, Shimaa; Umlai, Umm-Kulthum; Jan, Zainab; Gandhi, Geethanjali; Manickam, Chidambaram; Selvaraj, Senthil; George, Chinnu; Bangarusamy, Dhinoth; Abdel-latif, Rania; Al-Shafai, Mashael; Tatari-Calderone, Zohreh; Estivill, Xavier; Pirmohamed, Munir; Abdel-latif, Rania; Saqri, Tariq Abu; Zaid, Tariq Abu; Afifi, Nahla; Al-Ali, Rashid; Al-Khodor, Souhaila; Al-Muftah, Wadha; Al-Sarraj, Yasser; Albagha, Omar; Alkhayat, Eiman; Alkuwari, Fatima; Almabrazi, Hakeem; Alshafai, Mashael; Althani, Asmaa; Alvi, Muhammad; Badii, Ramin; Badji, Radja; Chouchane, Lotfi; Darwish, Dima; El Khouly, Ahmed; Ennaifar, Maryem; Estivill, Xavier; Fadl, Tasnim; Fakhro, Khalid; Fethnou, Eleni; Hamza, Mehshad; Ismail, Said I.; Jithesh, Puthen V.; Khatib, Mohammedhusen; Liu, Wei; Lorenz, Stephan; Mbarek, Hamdi; Mokrab, Younes; Pathare, Tushar; Poolat, Shafeeq; Qafoud, Fatima; Vempalli, Fazulur Rehaman; Saad, Chadi; Suhre, Karsten; Syed, Najeeb; Tatari, Zohreh; Temanni, Ramzi; Tomei, Sara; Yasin, Heba... more authors ... less authors ( Nature Research , 2022 , Article)Clinical implementation of pharmacogenomics will help in personalizing drug prescriptions and alleviate the personal and financial burden due to inefficacy and adverse reactions to drugs. However, such implementation is ... -
Mendelian inheritance of trimodal CpG methylation sites suggests distal cis-acting genetic effects.
Zaghlool, Shaza B; Al-Shafai, Mashael; Al Muftah, Wadha A; Kumar, Pankaj; Gieger, Christian; Waldenberger, Melanie; Falchi, Mario; Suhre, Karsten... more authors ... less authors ( BioMed Central , 2016 , Article)Environmentally influenced phenotypes, such as obesity and insulin resistance, can be transmitted over multiple generations. Epigenetic modifications, such as methylation of DNA cytosine-guanine (CpG) pairs, may be carriers ... -
PopPAnTe: population and pedigree association testing for quantitative data.
Visconti, Alessia; Al-Shafai, Mashael; Al Muftah, Wadha A; Zaghlool, Shaza B; Mangino, Massimo; Suhre, Karsten; Falchi, Mario... more authors ... less authors ( BioMed Central , 2017 , Article)Family-based designs, from twin studies to isolated populations with their complex genealogical data, are a valuable resource for genetic studies of heritable molecular biomarkers. Existing software for family-based studies ... -
Qatar genome: Insights on genomics from the Middle East
Mbarek, Hamdi; Devadoss Gandhi, Geethanjali; Selvaraj, Senthil; Al-Muftah, Wadha; Badji, Radja; Al-Sarraj, Yasser; Saad, Chadi; Darwish, Dima; Alvi, Muhammad; Fadl, Tasnim; Yasin, Heba; Alkuwari, Fatima; Razali, Rozaimi; Aamer, Waleed; Abbaszadeh, Fatemeh; Ahmed, Ikhlak; Mokrab, Younes; Suhre, Karsten; Albagha, Omar; Fakhro, Khalid; Badii, Ramin; Ismail, Said I.; Althani, Asma... more authors ... less authors ( Wiley , 2022 , Article)Despite recent biomedical breakthroughs and large genomic studies growing momentum, the Middle Eastern population, home to over 400 million people, is underrepresented in the human genome variation databases. Here we ...