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Accredited genetic testing in the Arab Gulf region: reinventing the wheel.
( Nature Publishing Group , 2016 , Article)Accredited genetic testing in the Arab Gulf region: reinventing the wheel. -
A decade of intestinal protozoan epidemiology among settled immigrants in Qatar
( PubMed Central , 2016 , Article)Background: The World Health Organization estimates that about 3.5 billion people worldwide are affected by intestinal parasitic infections. Reports have already emphasized the role of immigrants in outbreaks of ... -
Metabolic shift toward oxidative phosphorylation in docetaxel resistant prostate cancer cells
( Impact Journals , 2016 , Article)Drug resistance of cancer cells is recognized as the primary cause of failure of chemotherapeutic treatment in most human cancers. Growing evidences support the idea that deregulated cellular metabolism is linked to such ... -
Severe neurological manifestations in an Egyptian patient with a novel frameshift mutation in the Glutaryl-CoA dehydrogenase gene
( Springer US , 2016 , Article)Abstract To characterize an Egyptian patient with glutaric acidemia type I (GA I) and to identify the causative mutation( s) that may be responsible for the disease phenotype. MRI was performed on the patient using the ... -
Bidirectional communication between the Aryl hydrocarbon Receptor (AhR) and the microbiome tunes host metabolism
( Nature Publishing Group in partnership with Nanyang Technological University , 2016 , Article)The ligand-induced transcription factor, aryl hydrocarbon receptor (AhR) is known for its capacity to tune adaptive immunity and xenobiotic metabolism-biological properties subject to regulation by the indigenous microbiome. ... -
Activation of the Pro-Oxidant PKCβII-p66Shc Signaling Pathway Contributes to Pericyte Dysfunction in Skeletal Muscles of Diabetic Patients with Critical Limb Ischemia
( American Diabetes Association , 2016 , Article)Critical limb ischemia (CLI), foot ulcers, former amputation and impaired regeneration are independent risk factors for limb amputation in diabetic subjects. The present work investigates whether and by which mechanism ... -
Fabrication & Characterization of 3D Electrospun Biodegradable Nanofibers for Wound Dressing, Drug Delivery and Other Tissue Engineering Applications
( Bentham Science , 2016 , Article)Background: The use of electrospinning technology (ET) in fabrication of threedimensional biodegradable electrospun nanofibers scaffolds (BENS) has recently gained considerable attention in tissue engineering. BENS are ... -
Molecular dynamics-based analyses of the structural instability and secondary structure of the fibrinogen gamma chain protein with the D356V mutation.
( Taylor & Francis , 2016 , Article)Mutations in the fibrinogen gamma chain (FGG) gene have been associated with various disorders, such as dysfibrinogenemia, thrombophilia, and hypofibrinogenemia. A literature survey showed that a residue exchange in ... -
Identification of the Main Intermediate Precursor of l-Ergothioneine Biosynthesis in Human Biological Specimens
( MDPI AG , 2016 , Article)A capillary electrophoresis coupled to tandem mass spectrometry (CE–MS/MS) has been used to make a qualitative determination of hercynine—the main precursor of l-ergothioneine biosynthesis—in some key human biological ... -
The Qatar genome project: translation of whole-genome sequencing into clinical practice.
( Wiley , 2016 , Article)Qatar Genome Project was launched in 2013 with the intent to sequence the genome of each Qatari citizen in an effort to protect Qataris from the high rate of indigenous genetic diseases by allowing the mapping of disease-causing ... -
The Role of Cardiac Myosin Binding Protein C3 in Hypertrophic Cardiomyopathy- Progress and Novel Therapeutic Opportunities
( Wiley , 2016 , Article)Hypertrophic cardiomyopathy (HCM) is a common autosomal dominant genetic cardiovascular disorder marked by genetic and phenotypic heterogeneity. Mutations in the gene encodes the cardiac myosin-binding protein C, cMYBPC3 ... -
The Arab genome: Health and wealth
( Elsevier B.V. , 2016 , Article)The 22 Arab nations have a unique genetic structure, which reflects both conserved and diverse gene pools due to the prevalent endogamous and consanguineous marriage culture and the long history of admixture among different ... -
Genetic Epidemiology of Glucose-6-Dehydrogenase Deficiency in the Arab World
( Nature Publishing Group , 2016 , Article)A systematic search was implemented using four literature databases (PubMed, Embase, Science Direct and Web of Science) to capture all the causative mutations of Glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDD) ... -
Mendelian inheritance of trimodal CpG methylation sites suggests distal cis-acting genetic effects.
( BioMed Central , 2016 , Article)Environmentally influenced phenotypes, such as obesity and insulin resistance, can be transmitted over multiple generations. Epigenetic modifications, such as methylation of DNA cytosine-guanine (CpG) pairs, may be carriers ... -
Assessing the burden of intestinal parasites affecting newly arrived immigrants in Qatar
( BioMed Central , 2016 , Article)In the last decades, the enormous influx of immigrants to industrialized countries has led to outbreaks of parasitic diseases, with enteric infections being amongst the most frequently encountered. In its strategy to control ... -
Antibiotic Prescription Patterns for Upper Respiratory Tract Infections in Outpatient Qatari Population in the Private Sector
( Elsevier , 2016 , Article)Background: Antibiotic are often inappropriately prescribed for upper respiratory infections (URI) in the Western countries. Data on the proportion of inappropriate prescriptions are lacking from the Middle East and other ... -
Associations of Vitamin D Receptor Polymorphism rs1544410 with Adiposity Phenotypes
( MedCrave , 2016 , Article)Background: Vitamin D receptor (VDR) is present on adipocytes, and many studies were performed to investigate the association between polymorphisms in VDR gene with obesity. However, in the Arab Gulf populations, whereas ... -
The frequency of polycystic ovary syndrome in young reproductive females in Qatar
( Dove Medical Press , 2016 , Article)This was a prospective cross-sectional study in which 126 female students between the ages of 18 and 30 years were evaluated for the frequency of polycystic ovary syndrome (PCOS) through clinical interview, questionnaire, ... -
Prevalence of anelloviruses (TTV, TTMDV, and TTMV) in healthy blood donors and in patients infected with HBV or HCV in Qatar
( BioMed Central , 2016 , Article)Background Anelloviruses (TTV, TTMV, and TTMDV) have been associated with non A-G hepatitis. The goal of the current study was to estimate the prevalence of these anelloviruses in Qatar. Methods A total of 607 blood ... -
Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa
( Taylor & Francis , 2017 , Article)Over the past two decades, studies have documented the wide-range anti-cancer effects of Nigella sativa, known as black seed or black cumin. Thymoquinone (TQ), its major active ingredient, has also been extensively studied ...