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Structural Analysis of G1691S Variant in the Human Filamin B Gene Responsible for Larsen Syndrome: A Comparative Computational Approach
(
Wiley Periodicals, Inc
, 2017 , Article)
Larsen syndrome (LRS) is a rare genetic disease associated with variable manifestations including skeletal malformations, dislocations of the large joints, and notable changes in facial and limb features. Genetic variants ...
Impaired Liver Size and Compromised Neurobehavioral Activity are Elicited by Chitosan Nanoparticles in the Zebrafish Embryo Model
(
MDPI
, 2019 , Article)
The use of chitosan nanoparticles (ChNPs) in various biological and environmental
applications is attracting great interest. However, potential side effects related to ChNP toxicity
remain the major limitation hampering ...
Chitosan gold nanoparticles for detection of amplified nucleic acids isolated from sputum
(
Elsevier
, 2017 , Article)
A platform for nucleic acid detection employing chitosan and chitosan coated gold nanoparticles (AuNPs)
was developed. Mycobacterium tuberculosis (MTB) was used as a model target. MTB DNA was extracted
from sputum using ...
Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa
(
Taylor & Francis
, 2017 , Article)
Over the past two decades, studies have documented the wide-range anti-cancer effects of Nigella sativa, known as black seed or black cumin. Thymoquinone (TQ), its major active ingredient, has also been extensively studied ...
Comparative Phylogenetic and Residue Analysis of Hepatitis C Virus E1 Protein from the Middle East and North Africa Region
(
Kowsar (Research Center for Gastroenterology and Liver Diseases, Tehran, Iran)
, 2019 , Article)
Hepatitis C virus (HCV) is a major public health problem in the Middle East and North Africa (MENA) region with an estimate of over 15 million chronically infected patients. However, molecular characterization of circulating ...
Adipose tissue dysfunction in cancer cachexia
(
Wiley Periodicals, Inc.
, 2018 , Article)
Cancer cachexia is a complex disorder that is driven by inflammation and metabolic imbalances, resulting in extreme weight loss. Adipose tissue, a main player in cancer cachexia, is an essential metabolic and secretory ...
Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach
(
Plos One
, 2017 , Article)
Maturity-onset diabetes of the young type 3 (MODY3) is a non-ketotic form of diabetes associated with poor insulin secretion. Over the past years, several studies have reported the association of missense mutations in the ...
Computational approach to unravel the impact of missense mutations of proteins (D2HGDH and IDH2) causing D-2-hydroxyglutaric aciduria 2.
(
Springer US
, 2018 , Article)
The 2-hydroxyglutaric aciduria (2-HGA) is a rare neurometabolic disorder that leads to the development of brain damage. It is classified into three categories: D-2-HGA, L-2-HGA, and combined D,L-2-HGA. The D-2-HGA includes ...
Antihypertensive indigenous lebanese plants: Ethnopharmacology and a clinical trial
(
MDPI AG
, 2019 , Article)
Hypertension is highly prevalent among the Lebanese adult population and is indeed the major cause of mortality in Lebanon. Traditional use of antihypertensive medicinal plants has long been practiced. The aim of this study ...
Associations of Vitamin D Receptor Polymorphism rs1544410 with Adiposity Phenotypes
(
MedCrave
, 2016 , Article)
Background: Vitamin D receptor (VDR) is present on adipocytes, and many studies were performed to investigate the association between polymorphisms in VDR gene with obesity. However, in the Arab Gulf populations, whereas ...