Browsing Laboratory Animal Research Center (Research) by Author "Macha, Muzafar"

Now showing items 1-9 of 9

    • Chemokine-cytokine networks in the head and neck tumor microenvironment 

      Nisar, Sabah; Yousuf, Parvaiz; Masoodi, Tariq; Wani, Nissar A.; Hashem, Sheema; ... more authors ( MDPI , 2021 , Article Review)
      Head and neck squamous cell carcinomas (HNSCCs) are aggressive diseases with a dismal patient prognosis. Despite significant advances in treatment modalities, the five-year survival rate in patients with HNSCC has improved ...

    • Claudin-1, A Double-Edged Sword in Cancer. 

      Bhat, Ajaz A; Syed, Najeeb; Therachiyil, Lubna; Nisar, Sabah; Hashem, Sheema; ... more authors ( MDPI , 2020 , Article Review)
      Claudins, a group of membrane proteins involved in the formation of tight junctions, are mainly found in endothelial or epithelial cells. These proteins have attracted much attention in recent years and have been implicated ...

    • Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy 

      Bhat, A.A.; Bhat, Ajaz A.; Nisar, Sabah; Maacha, Selma; Carneiro-Lobo, Tatiana Correa; ... more authors ( BMC , 2021 , Article Review)
      Esophageal cancer (EC) is a disease often marked by aggressive growth and poor prognosis. Lack of targeted therapies, resistance to chemoradiation therapy, and distant metastases among patients with advanced disease account ...

    • Insights Into the Role of CircRNAs: Biogenesis, Characterization, Functional, and Clinical Impact in Human Malignancies 

      Nisar, Sabah; Bhat, Ajaz A.; Singh, Mayank; Karedath, Thasni; Rizwan, Arshi; ... more authors ( Frontiers Media , 2021 , Article Review)
      Circular RNAs (circRNAs) are an evolutionarily conserved novel class of non-coding endogenous RNAs (ncRNAs) found in the eukaryotic transcriptome, originally believed to be aberrant RNA splicing by-products with decreased ...

    • Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments 

      Lone, Saife N.; Nisar, Sabah; Masoodi, Tariq; Singh, Mayank; Rizwan, Arshi; ... more authors ( BMC , 2022 , Article Review)
      Over the past decade, invasive techniques for diagnosing and monitoring cancers are slowly being replaced by non-invasive methods such as liquid biopsy. Liquid biopsies have drastically revolutionized the field of clinical ...

    • miRNAs as novel immunoregulators in cancer 

      Saife N., Lone; Bhat, Ajaz A.; Wani, Nissar A.; Karedath, Thasni; Hashem, Sheema; ... more authors ( Elsevier , 2021 , Article Review)
      The immune system is a well-known vital regulator of tumor growth, and one of the main hallmarks of cancer is evading the immune system. Immune system deregulation can lead to immune surveillance evasion, sustained cancer ...

    • The tumor microenvironment as driver of stemness and therapeutic resistance in breast cancer: New challenges and therapeutic opportunities 

      Mehraj, Umar; Ganai, Rais A.; Macha, Muzafar A.; Hamid, Abid; Zargar, Mohammed A.; ... more authors ( Springer , 2021 , Article Review)
      Background: Breast cancer (BC), the second most common cause of cancer-related deaths, remains a significant threat to the health and wellness of women worldwide. The tumor microenvironment (TME), comprising cellular ...

    • Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy. 

      Bhat, Ajaz A; Yousuf, Parvaiz; Wani, Nissar A; Rizwan, Arshi; Chauhan, Shyam S; ... more authors ( Springer Nature , 2021 , Article Review)
      Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease with a poor prognosis for advanced-stage tumors. Recent clinical, genomic, and cellular studies have revealed the highly heterogeneous and ...

    • Ubiquitin-specific peptidase 37: an important cog in the oncogenic machinery of cancerous cells. 

      Chauhan, Ravi; Bhat, Ajaz A; Masoodi, Tariq; Bagga, Puneet; Reddy, Ravinder; ... more authors ( BMC , 2021 , Article Review)
      Protein ubiquitination is one of the most crucial posttranslational modifications responsible for regulating the stability and activity of proteins involved in homeostatic cellular function. Inconsistencies in the ...