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المؤلفSotgia, Salvatore
المؤلفZinellu, Angelo
المؤلفMangoni, Arduino A
المؤلفSerra, Roberta
المؤلفPintus, Gianfranco
المؤلفCaruso, Calogero
المؤلفDeiana, Luca
المؤلفCarru, Ciriaco
تاريخ الإتاحة2017-11-14T10:29:08Z
تاريخ النشر2017-12-01
اسم المنشورExperimental Gerontology
المعرّفhttp://dx.doi.org/10.1016/j.exger.2017.10.005
الاقتباسSotgia, S., Zinellu, A., Mangoni, A. A., Serra, R., Pintus, G., Caruso, C., Deiana, L. and Carru, C. (2017)"Cellular immune activation in Sardinian middle-aged, older adults and centenarians" Experimental Gerontology, vol.99, pp. 133-137.
الرقم المعياري الدولي للكتاب0531-5565
معرّف المصادر الموحدhttp://hdl.handle.net/10576/5751
الملخصIn addition to viral infections, malignant disorders, autoimmune diseases, and allograft rejection episodes, neopterin increases in older people where it is found to be predictive of overall mortality. Thus, the serum concentrations of this biomarker of systemic immune and inflammation activation, were measured in a small cohort of Sardinian middle-aged, older adults and centenarians. There was a significant positive correlation between neopterin concentrations and age with the subjects in the 95-year-old group with the highest values. Notably, the group of centenarians had neopterin values comparable to those of 80- and 90-year-old groups, and significantly lower than that of 95-year-old group. This suggests a decreased monocyte/macrophage-mediated immune activation and an apparently preserved immune status in centenarians.
اللغةen
الناشرElsevier
الموضوعInflammaging
Pteridines
Aging
Immunosenescence
Longevity
Centenarians
Cytokines
العنوانCellular immune activation in Sardinian middle-aged, older adults and centenarians
النوعArticle
الصفحات133-137
رقم المجلد99
ESSN1873-6815


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