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Internalization of metal-organic framework nanoparticles in human vascular cells: Implications for cardiovascular disease therapy
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2020 , Article)
Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Alteration of endothelial cells and the underlying vasculature plays a central role in the pathogenesis of various CVDs. The ...
Studies on metal–organic framework (MOF) nanomedicine preparations of sildenafil for the future treatment of pulmonary arterial hypertension
(
nature
, 2021 , Article)
Pulmonary arterial hypertension (PAH) is an incurable disease, although symptoms are treated with a range of dilator drugs. Despite their clinical benefits, these drugs are limited by systemic side-effects. It is, therefore, ...