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Inhibition of p90 ribosomal S6 kinase potentiates cisplatin activity in A549 human lung adenocarcinoma cells
(
Wiley
, 2020 , Article)
© 2020 Royal Pharmaceutical Society Aim: Cisplatin is a standard treatment approach against lung adenocarcinoma. Resistance to cisplatin and the toxic side effects of cisplatin continue to remain a challenge. Combining ...
The Cellular Interplay Between CD44 and Na+/H+ Exchanger1 in Cardiac Remodeling
(
Hamad bin Khalifa University Press (HBKU Press)
, 2018 , Conference Paper)
Background: Extracellular matrix (ECM) remodeling is a characteristic feature of cardiac remodeling which, if left untreated, progresses to heart failure. Cardiac fibroblasts, the major cellular component of the myocardium, ...
The Role of p90 Ribosomal S6 Kinase (RSK) in Tyrosine Kinase Inhibitor (TKI)-Induced Cardiotoxicity
(
Springer
, 2023 , Article Review)
Targeted therapy, such as tyrosine kinase inhibitors (TKIs), has been approved to manage various cancer types. However, TKI-induced cardiotoxicity is a limiting factor for their use. This issue has raised the need for ...