Browsing by Author "Abou-Saleh, Haissam"
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Anticancer Activity of Guggulsterone in Multiple Myeloma Cells
Zarif, Lubna (2021 , Master Thesis)Guggulsterone (GS), a phytosteroid derived from guggul plants' gum resin, has anti-inflammatory and antioxidant properties. Although, the GS is found to have cytotoxic effects in Multiple Myeloma (MM) cells, the ... -
Assessment of Metal Organic Framework as Potential Drug Carriers in Cardiovascular Diseases
Al-Ansari, Dana E.; Mohamed, Nura A.; Marei, Isra; Yalcin, Huseyin; Abou-Saleh, Haissam ( Qatar University Press , 2020 , Poster)Background: Cardiovascular diseases (CVDs) are considered the major cause of death worldwide. Therapeutic delivery to the cardiovascular system may play an important role in the successful treatment of a variety of CVDs, ... -
Assessment of the Neutralizing Antibody Response of BNT162b2 and mRNA-1273 SARS-CoV-2 Vaccines in Naïve and Previously Infected Individuals: A Comparative Study
Shurrab, Farah M.; Al-Sadeq, Duaa W.; Abou-Saleh, Haissam; Al-Dewik, Nader; Elsharafi, Amira E.; Hamaydeh, Fatima M.; Abo Halawa, Bushra Y.; Jamaleddin, Tala M.; Abdul Hameed, Huda M.; Nizamuddin, Parveen B.; Amanullah, Fathima Humaira; Daas, Hanin I.; Abu-Raddad, Laith J.; Nasrallah, Gheyath K.... more authors ... less authors ( MDPI , 2022 , Report)The currently authorized mRNA COVID-19 vaccines, Pfizer-BNT162b2 and Moderna-mRNA-1273, offer great promise for reducing the spread of the COVID-19 by generating protective immunity against SARS-CoV-2. Recently, it was ... -
Effect of Hyperglycemia on eNOS function in EPCs
Elshiekh, Duaa Ibnomer; Hendawi, Hadeel; Goul, Aya; Awartani, Dina; Marei, Isra; Triggle, Christopher; Abou Saleh, Haissam... more authors ... less authors ( Qatar University Press , 2020 , Poster)Type 2 diabetes mullites (T2DM) results in different cardiovascular complications. The main cause of these complications is endothelial dysfunction, which affects the endothelium physiologically and pathologically. The ... -
Effect of hyperglycemia on EPCs function and regenerative ability
Hendawi, Hadeel Khalil; Awartani, Dina Nehad; Ghoul, Aya; Marei, Isra; Abou Saleh, Haissam; Triggle, Christopher... more authors ... less authors ( Qatar University Press , 2020 , Poster)Diabetes induced hyperglycemia increases the risk of cardiovascular complications as it impacts vascular endothelial cells causing vascular dysfunction. Endothelial progenitor cells (EPCs) have been suggested to participate ... -
Epstein–Barr Virus Epidemiology, Serology, and Genetic Variability of LMP-1 Oncogene Among Healthy Population: An Update
Smatti, Maria K.; Al-Sadeq, Duaa W.; Ali, Nadima H.; Pintus, Gianfranco; Abou-Saleh, Haissam; Nasrallah, Gheyath K.... more authors ... less authors ( Frontiers Medi , 2018 , Article Review)The Epstein–Barr virus (EBV) is a DNA lymphotropic herpesvirus and the causative agent of infectious mononucleosis. EBV is highly prevalent since it affects more than 90% of individuals worldwide and has been linked to ... -
Evaluation of Metal-Organic Framework MIL-89 Nanoparticles Toxicity on Embryonic Zebrafish Development
Dana E., Al-Ansari; Al-Badr, Mashael; Zakaria, Zain Z.; Mohamed, Nura Adam; Nasrallah, Gheyath K.; Yalcin, Huseyin C.; Abou-Saleh, Haissam... more authors ... less authors ( Elsevier , 2022 , Article)Metal-Organic Framework MIL-89 nanoparticles garnered remarkable attention for their widespread use in technological applications. However, the impact of these nanomaterials on human and environmental health is still ... -
Flavin Oxidase-Induced ROS Generation Modulates PKC Biphasic Effect of Resveratrol on Endothelial Cell Survival.
Posadino, Anna Maria; Giordo, Roberta; Cossu, Annalisa; Nasrallah, Gheyath K; Shaito, Abdullah; Abou-Saleh, Haissam; Eid, Ali H; Pintus, Gianfranco... more authors ... less authors ( MDPI , 2019 , Article)Dietary intake of natural antioxidants is thought to impart protection against oxidative-associated cardiovascular diseases. Despite many in vivo studies and clinical trials, this issue has not been conclusively resolved. ... -
Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals over 10 months
Salma, Younes; Nicolai, Eleonora; Al-Sadeq, Duaa W.; Younes, Nadin; Al-Dewik, Nader; Abou-Saleh, Haissam; Abo-Halawa, Bushra Y.; Eid, Ali Hussein; Pieri, Massimo; Liu, Na; Daas, Hanin I.; Yassine, Hadi M.; Nizamuddin, Parveen B.; Abu-Raddad, Laith J.; Nasrallah, Gheyath K.... more authors ... less authors ( Elsevier , 2023 , Article)BackgroundEvidence on the effectiveness of vaccination-induced immunity compared to SARS-CoV-2 natural immunity is warranted to inform vaccination recommendations. AimIn this study, we aimed to conduct a comparative ... -
Guggulsterone Induces Apoptosis in Multiple Myeloma Cells by Targeting High Mobility Group Box 1 via Janus Activated Kinase/Signal Transducer and Activator of Transcription Pathway
Akhtar, Sabah; Zarif, Lubna; Kuttikrishnan, Shilpa; Prabhu, Kirti S.; Patil, Kalyani; Nisar, Sabah; Abou-Saleh, Haissam; Merhi, Maysaloun; Dermime, Said; Bhat, Ajaz A.; Uddin, Shahab... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Multiple myeloma (MM) is a hematological disorder characterized by the abnormal expansion of plasma cells in the bone marrow. Despite great advances over the past three decades in discovering the efficacious therapies for ... -
Impacts on Student Learning and Skills and Implementation Challenges of Two Student-Centered Learning Methods Applied in Online Education
soubra, lama; al Ghouti, Mohamed; Abu diyeh, Mohamed; Crovella, sergio; Abou saleh, Haissam ( MDPI , 2022 , Article)Online education became more prevalent during the COVID-19 pandemic in many countries around the world, including the Gulf Cooperation Council (GCC) countries. This study aims at assessing the impacts on learning and skills ... -
Impaired Liver Size and Compromised Neurobehavioral Activity are Elicited by Chitosan Nanoparticles in the Zebrafish Embryo Model
Abou-Saleh, Haissam; Younes, Nadin; Rasool, Kashif; Younis, Manaf H.; Prieto, Rafael M.; Yassine, Hadi M.; Mahmoud, Khaled A.; Pintus, Gianfranco; Nasrallah, Gheyath K.... more authors ... less authors ( MDPI , 2019 , Article)The use of chitosan nanoparticles (ChNPs) in various biological and environmental applications is attracting great interest. However, potential side effects related to ChNP toxicity remain the major limitation hampering ... -
Inositol 1,4,5-Trisphosphate Receptors in Hypertension.
Eid, Ali H; El-Yazbi, Ahmed F; Zouein, Fouad; Arredouani, Abdelilah; Ouhtit, Allal; Rahman, Md M; Zayed, Hatem; Pintus, Gianfranco; Abou-Saleh, Haissam... more authors ... less authors ( Frontiers Media , 2018 , Article Review)Chronic hypertension remains a major cause of global mortality and morbidity. It is a complex disease that is the clinical manifestation of multiple genetic, environmental, nutritional, hormonal, and aging-related disorders. ... -
Internalization of metal-organic framework nanoparticles in human vascular cells: Implications for cardiovascular disease therapy
Al-Ansari, Dana E.; Mohamed, Nura A.; Marei, Isra; Zekri, Atef; Kameno, Yu; Davies, Robert P.; Lickiss, Paul D.; Rahman, Md Mizanur; Abou-Saleh, Haissam... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2020 , Article)Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Alteration of endothelial cells and the underlying vasculature plays a central role in the pathogenesis of various CVDs. The ... -
The march of pluripotent stem cells in cardiovascular regenerative medicine.
Abou-Saleh, Haissam; Zouein, Fouad A; El-Yazbi, Ahmed; Sanoudou, Despina; Raynaud, Christophe; Rao, Christopher; Pintus, Gianfranco; Dehaini, Hassan; Eid, Ali H... more authors ... less authors ( BMC , 2018 , Article Review)Cardiovascular disease (CVD) continues to be the leading cause of global morbidity and mortality. Heart failure remains a major contributor to this mortality. Despite major therapeutic advances over the past decades, a ... -
Microalgae potential to protect from heavy metals-induced carcinogenicity
Hadjira, Hamai-Amara; Abou-Saleh, Haissam; A. Al-Ghouti, Mohammad; Crovella, Sergio; Saadaoui, Imen; Soubra, Lama... more authors ... less authors ( Elsevier , 2024 , Article)Toxic elements are present naturally in the environment; however, during the last century, their level has been continuously rising in the air, water, and soil due to anthropogenic activities, including urban runoff, ... -
Multiomics integration in skin diseases with alterations in notch signaling pathway: PlatOMICs phase 1 deployment
Brandão, Lucas André Cavalcanti; Tricarico, Paola Maura; Gratton, Rossella; Agrelli, Almerinda; Zupin, Luisa; Abou-Saleh, Haissam; Moura, Ronald; Crovella, Sergio... more authors ... less authors ( MDPI , 2021 , Article Review)The high volume of information produced in the age of omics was and still is an important step to understanding several pathological processes, providing the enlightenment of complex molecular networks and the identification ... -
Neuropathy of type 1 diabetes in the Arab world: A systematic review and meta-analysis
Abdel-Motal, Ussama M.; Abdelalim, Essam M.; Abou-Saleh, Haissam; Zayed, Hatem ( Elsevier , 2017 , Article)Abstract AimsAlthough type 1 diabetes (T1D) is a common disease in the Arab nations, there is no data available on the prevalence of peripheral neuropathy (PN) among T1D subjects in Arab countries. The aim of this study ... -
Neutralizing antibodies against SARS-CoV-2 are higher but decline faster in mRNA vaccinees compared to individuals with natural infection.
Abou-Saleh, Haissam; Abo-Halawa, Bushra Y; Younes, Salma; Younes, Nadin; Al-Sadeq, Duaa W; Shurrab, Farah M; Liu, Na; Qotba, Hamda; Al-Dewik, Nader; Ismail, Ahmed; Yassine, Hadi M; Abu-Raddad, Laith J; Nasrallah, Gheyath K... more authors ... less authors ( Oxford University Press , 2022 , Article)Waning protection against emerging SARS-CoV-2 variants by pre-existing antibodies elicited due to current vaccination or natural infection is a global concern. Whether this is due to the waning of immunity to SARS-COV-2 ... -
Novel CD44-downstream signaling pathways mediating breast tumor invasion
Ouhtit, Allal; Rizeq, Balsam; Abou Saleh, Haissam; Rahman, MD Mizanur; Zayed, Hatem ( Ivyspring International Publisher , 2018 , Article Review)CD44, also known as homing cell adhesion molecule is a multi-structural cell molecule involved in cell-cell and cell-extracellular matrix communications. CD44 regulates a number of central signaling pathways, including ...