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Oxidative stress-induced Akt downregulation mediates green tea toxicity towards prostate cancer cells
(
Elsevier
, 2017 , Article)
Green tea consumption has been shown to possess cancer chemopreventive activity. Polyphenol E (PE) is a widely used standardized green tea extract formulation. This study was designed to investigate the impact of PE on ...
Nose-to-brain delivery of BACE1 siRNA loaded in solid lipid nanoparticles for Alzheimer’s therapy
(
Elsevier
, 2017 , Article)
Abstract We designed a delivery system to obtain an efficient and optimal nose-to-brain transport of BACE1 siRNA, potentially useful in the treatment of Alzheimer's disease. We selected a cell-penetrating peptide, the short ...
Bioavailability and hypolipidemic effects of peanut skin polyphenols
(
Mary Ann Liebert, Inc.
, 2015 , Article)
Peanut skin is a rich source of polyphenols, such as proanthocyanidins. Peanut skin proanthocyanidins mainly
consist of a subgroup called procyanidins. Peanut-based procyanidins contain oligomers of both type A and type ...
Clinical Exome Sequencing unravels new disease-causing mutations in the myeloproliferative neoplasms: A pilot study in patients from the state of Qatar.
(
Elsevier
, 2018 , Article)
Clinical Exome Sequencing (CES) has increasingly become a popular diagnostic tool in patients suffering from genetic disorders that are clinically and genetically complicated. Myeloproliferative Neoplasms (MPNs) is an ...
Glycemic index of selected carbohydrate-based foods consumed in Qatar
(
Taylor & Francis
, 2010 , Article)
This study determined the glycemic index (GI) of selected carbohydrate-rich foods consumed in
Qatar. Recruited volunteers (n = 19) consumed two reference foods, glucose and white bread,
and 10 test foods. The foods tested ...
Neuropathy of type 1 diabetes in the Arab world: A systematic review and meta-analysis
(
Elsevier
, 2017 , Article)
Abstract AimsAlthough type 1 diabetes (T1D) is a common disease in the Arab nations, there is no data available on the prevalence of peripheral neuropathy (PN) among T1D subjects in Arab countries. The aim of this study ...
Bioactive compounds isolated from apple, tea, and ginger protect against dicarbonyl induced stress in cultured human retinal epithelial cells
(
Elsevier
, 2016 , Article)
Abstract BackgroundMethylglyoxal (MGO) is known to be a major precursor of advanced glycation end products (AGEs) which are linked to diabetes and its related complications. Naturally occurring bioactive compounds could ...
Structural Analysis of G1691S Variant in the Human Filamin B Gene Responsible for Larsen Syndrome: A Comparative Computational Approach
(
Wiley Periodicals, Inc
, 2017 , Article)
Larsen syndrome (LRS) is a rare genetic disease associated with variable manifestations including skeletal malformations, dislocations of the large joints, and notable changes in facial and limb features. Genetic variants ...
Green tea epigallocatechin 3-gallate alleviates hyperglycemia and reduces advanced glycation end products via nrf2 pathway in mice with high fat diet-induced obesity
(
Elsevier
, 2017 , Article)
Abstract Epigallocatechin 3-gallate (EGCG) from green tea may reduce plasma glucose and alleviate complications of diabetes by attenuating advanced glycation end products (AGEs) formation. We hypothesized that EGCG would ...
Chitosan gold nanoparticles for detection of amplified nucleic acids isolated from sputum
(
Elsevier
, 2017 , Article)
A platform for nucleic acid detection employing chitosan and chitosan coated gold nanoparticles (AuNPs)
was developed. Mycobacterium tuberculosis (MTB) was used as a model target. MTB DNA was extracted
from sputum using ...