Browsing Academic by Author "Burgon, Patrick G."

Now showing items 1-4 of 4

    • Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs) as a Platform for Modeling Arrhythmias 

      Lin, Lisa; Barszczewski, Tiffany; Burgon, Patrick G.; Tibbits, Glen F. ( Springer Nature , 2022 , Book chapter)
      Cardiac arrhythmias can arise due to a host of both genetic and acquired factors. Specifically, the genetic basis of arrhythmogenesis is not fully understood due to the lack of robust models that reliably recapitulate human ...

    • MLIP causes recessive myopathy with rhabdomyolysis, myalgia and baseline elevated serum creatine kinase 

      Lopes Abath Neto, Osorio; Medne, Livija; Donkervoort, Sandra; Rodríguez-García, Maria Elena; Bolduc, Véronique; ... more authors ( Oxford University Press , 2021 , Article)
      Striated muscle needs to maintain cellular homeostasis in adaptation to increases in physiological and metabolic demands. Failure to do so can result in rhabdomyolysis. The identification of novel genetic conditions ...

    • Muscle enriched lamin interacting protein (Mlip) binds chromatin and is required for myoblast differentiation 

      Ahmady, Elmira; Blais, Alexandre; Burgon, Patrick G. ( MDPI , 2021 , Article)
      Muscle‐enriched A‐type lamin‐interacting protein (Mlip) is a recently discovered Amniota gene that encodes proteins of unknown biological function. Here we report Mlip’s direct interaction with chromatin, and it may function ...

    • Regulatory Mechanisms That Guide the Fetal to Postnatal Transition of Cardiomyocytes 

      Burgon, Patrick G.; Weldrick, Jonathan J.; Talab, Omar Mohamed Sayed Ahmed; Nadeer, Muhammad; Nomikos, Michail; ... more authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)
      Heart disease remains a global leading cause of death and disability, necessitating a comprehensive understanding of the heart’s development, repair, and dysfunction. This review surveys recent discoveries that explore the ...