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The Role of p90 Ribosomal S6 Kinase (RSK) in Tyrosine Kinase Inhibitor (TKI)-Induced Cardiotoxicity
(
Springer
, 2023 , Article Review)
Targeted therapy, such as tyrosine kinase inhibitors (TKIs), has been approved to manage various cancer types. However, TKI-induced cardiotoxicity is a limiting factor for their use. This issue has raised the need for ...
Computational Analysis of Wall Shear Stress Patterns on Calcified and Bicuspid Aortic Valves : Focus on Radial and Coaptation Patterns
(
MDPI
, 2021 , Article)
Calcification and bicuspid valve formation are important aortic valve disorders that disturb the hemodynamics and the valve function. The detailed analysis of aortic valve hemodynamics would lead to a better understanding ...
In vivo testing of novel nitric oxide-releasing nanoparticles for alleviating heart failure using the zebrafish embryo model
(
Elsevier
, 2024 , Article)
Heart failure (HF) is a multifactorial, heterogeneous systemic disease that is considered one of the leading causes of death and morbidity worldwide. It is well-known that endothelial dysfunction (ED) plays an important ...
Editorial: Advances in techniques for measurement and assessment of physiological processes in developing animals
(
Frontiers Media
, 2023 , Other)
Developmental Physiology can be broadly defined as the field of science aiming to
understand the physiological processes shaping a fertilized egg of a species into a wellstructured
and functional multi-cellular organism. ...
Disturbed hemodynamics and oxidative stress interaction in endothelial dysfunction and AAA progression: Focus on Nrf2 pathway
(
Elsevier
, 2023 , Article Review)
Hemodynamic shear stress is one of the major factors that are involved in the pathogenesis of many cardiovascular diseases including atherosclerosis and abdominal aortic aneurysm (AAA), through its modulatory effect on the ...
Deep Learning Technique for Congenital Heart Disease Detection Using Stacking-Based CNN-LSTM Models from Fetal Echocardiogram: A Pilot Study
(
IEEE
, 2023 , Article)
Congenital heart defects (CHDs) are a leading cause of death in infants under 1 year of age. Prenatal intervention can reduce the risk of postnatal serious CHD patients, but current diagnosis is based on qualitative criteria, ...
Trilayer composite scaffold for urethral reconstruction: in vitro evaluation of mechanical, biological, and angiogenic properties
(
IOP Publishing
, 2024 , Article)
Regeneration of damaged urethral tissue remains a major challenge in the field of lower urinary tract reconstruction. To address this issue, various synthetic and natural biodegradable biomaterials are currently being ...
Editorial: Emerging mechanisms in cardiovascular disease
(
Frontiers Media
, 2023 , Other)
Editorial on the Research Topic
Emerging mechanisms in cardiovascular disease
The leading cause of worldwide mortality is cardiovascular disease (CVD) (Aboukhater et al., 2023). Despite many significant advances in the ...
Development of Recombinant PLC-Zeta Protein as a Therapeutic Intervention for the Clinical Treatment of Oocyte Activation Failure
(
MDPI
, 2024 , Article)
The sperm-specific phospholipase C zeta (PLCζ) protein is widely considered as the predominant physiological stimulus for initiating the Ca2+ release responsible for oocyte activation during mammalian fertilization. The ...