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AuthorSobolčiak, P.
AuthorŠpírek, M.
AuthorKatrlík, J.
AuthorGemeiner, P.
AuthorLacík, I.
AuthorKasák, P.
Available date2015-11-05T09:24:17Z
Publication Date2013
Publication NameMacromolecular Rapid Communications
CitationSobolčiak, P., Špírek, M., Katrlík, J., Gemeiner, P., Lacík, I. and Kasák, P. (2013), Light-Switchable Polymer from Cationic to Zwitterionic Form: Synthesis, Characterization, and Interactions with DNA and Bacterial Cells. Macromol. Rapid Commun., 34: 635–639.
ISSN1521-3927
URIhttp://dx.doi.org/10.1002/marc.201200823
URIhttp://hdl.handle.net/10576/3672
AbstractA novel cationic polymer poly(N,N-dimethyl-N-[3-(methacroylamino) propyl]-N-[2-[(2-nitrophenyl)methoxy]-2-oxo-ethyl]ammonium chloride) is synthesized by free-radical polymerization of N-[3-(dimethylamino)propyl] methacrylamide and subsequent quaternization with o-nitrobenzyl 2-chloroacetate. The photolabile o-nitrobenzyl carboxymethyl pendant moiety is transformed to the zwitterionic carboxybetaine form upon the irradiation at 365 nm. This feature is used to condense and, upon the light irradiation, to release double-strand DNA tested by gel electrophoresis and surface plasmon resonance experiments as well as to switch the antibacterial activity to non-toxic character demonstrated for Escherichia coli bacterial cells in solution and at the surface using the self-assembled monolayers.
Languageen
PublisherWILEY-VCH Verlag
Subjectantibacterial
Subjectcarboxybetaine ester
SubjectdsDNA polyplex
Subjectphotochemistry
Subjectwater-soluble polymers
TitleLight-Switchable Polymer from Cationic to Zwitterionic Form: Synthesis, Characterization, and Interactions with DNA and Bacterial Cells
TypeArticle
Issue Number8
Volume Number34


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