Show simple item record

AuthorAbdulrashid, Khadiga
AuthorAlHussaini, Nour
AuthorAhmed, Wifag
AuthorThalib, Lukman
Available date2019-03-24T05:19:06Z
Publication Date2019-03-01
Publication NameBMC Canceren_US
Identifierhttp://dx.doi.org/10.1186/s12885-019-5463-1
CitationPrevalence of BRCA mutations among hereditary breast and/or ovarian cancer patients in Arab countries: systematic review and meta-analysis.
ISSN1471-2407
URIhttp://hdl.handle.net/10576/11454
AbstractTo systematically assess the prevalence of BRCA1 and BRCA2 gene mutations in women with Hereditary Breast and/or Ovarian Cancer (HBOC) in Arab countries and to describe the variability in the BRCA gene mutations in different regions of the Arab world. Observational studies reporting prevalence of BRCA mutations from 22 Arab countries were systematically searched in databases including PUBMED, EMBASE, Web of Science, and Google Scholar. Two reviewers independently screened the studies and extracted data and assessed the risk of bias. Hoy's risk of Bias tool was used to assess the biases in individual studies. Due to substantial heterogeneity, pooled weighted estimates were calculated using Quality Effect Models (QEM) that adjust for bias, while the Random Effect Models (REM) estimates served as the sensitivity estimates. Fourteen studies reporting prevalence of BRCA were included. The pooled estimate of BRCA among HBOC was 20% (95% CI: 7-36%). Subgroup analysis including only those with low risk of bias provided an estimate of 11% (95% CI: 1-27%). Levant region had higher prevalence 28% (95% CI: 11-49%) compared to Arabian Gulf region and North Africa but differences are not statistically significant, when tested using Z-test for proportions. Given the pooled estimates vary widely with substantial heterogeneity, larger, well-designed studies are warranted to better understand the frequency and the impact of BRCA gene mutations among Arab women. International Prospective Register of Systematic Reviews (PROSPERO) registration number: CRD42018095905 .
SponsorQNL
Languageen
PublisherBMC
SubjectArab countries
SubjectBRCA mutations
SubjectFamilial breast cancer
SubjectFamilial ovarian cancer
SubjectSystematic review, meta-analysis
TitlePrevalence of BRCA mutations among hereditary breast and/or ovarian cancer patients in Arab countries: systematic review and meta-analysis.
TypeArticle
Issue Number1
Volume Number19


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record