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AuthorNur, Ula
AuthorEl Reda, Darline
AuthorHashim, Dana
AuthorWeiderpass, Elisabete
Available date2019-09-18T06:46:31Z
Publication Date2019-08-01
Publication NameBMC Canceren_US
Identifierhttp://dx.doi.org/10.1186/s12885-019-5985-6
ISSN1471-2407
URIhttp://hdl.handle.net/10576/11883
AbstractThe association between oral contraceptive (OC) use and long-term mortality remains uncertain and previous studies have reported conflicting findings. We aim to assess the long-term impact of OC use on all-cause and cancer-specific mortality. Out of 49,259 participants, we analysed data on 2120 (4.3%) women diagnosed with first primary breast cancer between 1993 and 2012, in the Swedish Women's Lifestyle and Health Study. Kaplan-Meier plots were used to graph the hazard of mortality in association with oral contraceptives use, stage of disease and hormone receptors status at diagnosis. Cox proportional hazard model were used to estimate hazard ratios (HR) between OC use and all-cause mortality. The same association was studied for breast cancer-specific mortality by modelling the log cumulative mortality risk, adjusting for clinical stage at diagnosis, hormone receptor status, body mass index and smoking. Among 2120 women with breast cancer, 1268 (84%) reported ever use of OC and 254 died within 10 years of diagnosis. The risk of death for OC ever-users relative to never-users was: HR = 1.13 (95% CI: 0.66-1.94) for all-cause mortality and HR = 1.29 (95% CI: 0.53-3.18) for breast cancer-specific mortality. A high percentage of women (42.9%) were diagnosed at early stage disease (stage I). Among women with primary breast cancer, OC ever-users compared to never- users did not have a higher all-cause or breast cancer specific-mortality, after the adjustment of risk factors.
SponsorPublication of this work have been funded by Qatar National Library. The funding body had no role in the study design, data collection and analysis, interpretation of the data and results, or in writing the manuscript.
Languageen
PublisherBMC
SubjectBreast cancer
SubjectHormone receptor status
SubjectMultiple imputation
SubjectOral contraceptives
SubjectStage
SubjectSurvival
TitleA prospective investigation of oral contraceptive use and breast cancer mortality: findings from the Swedish women's lifestyle and health cohort.
TypeArticle
Volume Number19


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