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AuthorRizeq, Balsam R
AuthorYounes, Nadin N
AuthorRasool, Kashif
AuthorNasrallah, Gheyath K
Available date2019-11-24T05:40:59Z
Publication Date2019-11-01
Publication NameInternational Journal Of Molecular Sciencesen_US
Identifierhttp://dx.doi.org/10.3390/ijms20225776
CitationRizeq, B.R.; Younes, N.N.; Rasool, K.; Nasrallah, G.K. Synthesis, Bioapplications, and Toxicity Evaluation of Chitosan-Based Nanoparticles. Int. J. Mol. Sci. 2019, 20, 5776.
IdentifierArticle # 5776
URIhttp://hdl.handle.net/10576/12328
AbstractThe development of advanced nanomaterials and technologies is essential in biomedical engineering to improve the quality of life. Chitosan-based nanomaterials are on the forefront and attract wide interest due to their versatile physicochemical characteristics such as biodegradability, biocompatibility, and non-toxicity, which play a promising role in biological applications. Chitosan and its derivatives are employed in several applications including pharmaceuticals and biomedical engineering. This article presents a comprehensive overview of recent advances in chitosan derivatives and nanoparticle synthesis, as well as emerging applications in medicine, tissue engineering, drug delivery, gene therapy, and cancer therapy. In addition to the applications, we critically review the main concerns and mitigation strategies related to chitosan bactericidal properties, toxicity/safety using tissue cultures and animal models, and also their potential environmental impact. At the end of this review, we also provide some of future directions and conclusions that are important for expanding the field of biomedical applications of the chitosan nanoparticles.
Languageen
PublisherMDPI
SubjectChitosan
Subjectbiomedical
Subjectnanoparticles
Subjectpharmaceuticals
Subjecttoxicity
TitleSynthesis, Bioapplications, and Toxicity Evaluation of Chitosan-Based Nanoparticles.
TypeArticle
Issue Number22
Volume Number20


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