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MOLECULAR FEATURES OF TRIPLE NEGATIVE BREAST CANCER STEM CELLS: A GENE EXPRESSION PROFILING ANALYSIS OF MDA-MB-231 CELLS
(Pharmacy, 2021 , Master Thesis)
Triple negative breast cancer (TNBC) is a chemoresistant subtype of female breast tumors. Chemoresistance is attributed to the presence of long-lived cancer stem cells (CSCs) responsible for therapy failure. This study ...
CLINICAL AND PHARMACOECONOMIC ANALYSES OF CDK4/6 INHIBITORS USE IN STAGE IV BREAST CANCER FEMALES IN THE STATE OF QATAR: A COMPARATIVE RETROSPECTIVE OBSERVATIONAL STUDY WITH COST-EFFECTIVENESS AND COST-UTILITY ANALYSES
(Pharmacy, 2021 , Master Thesis)
Introduction: Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are indicated in the first-line treatment of hormonal receptor positive and HER-2 negative (HR+/HER2- negative) advanced breast cancer. Although phase III ...
COMMUNITY PHARMACISTS' SELF-PERCEIVED COMPETENCY, AND ENABLERS, AND BARRIERS TOWARDS THE MANAGEMENT OF COMMON MINOR AILMENTS IN QATAR
(Pharmacy, 2021 , Master Thesis)
The study aimed to assess community pharmacists' self-perceived competency, and enablers and barriers towards managing common minor ailments in Qatar, and its predictors. A cross-sectional study, with pretested questionnaires, ...
SUCCINYLATED CURCUMIN LOADED IN MANNOSYLATED CHITOSAN NANOPARTICLES FOR COLON CANCER THERAPY
(Pharmacy, 06-2 , Master Thesis)
Colon cancer (CRC) is the second leading cause of death and the third most diagnosed type worldwide. Although curcumin (CUR) has potent anticancer activity, it suffers from low solubility, bioavailability, and instability. ...
THE EFFECT OF NATURAL AND SYNTHETIC COMPOUNDS ON COLORECTAL CANCER: IN VITRO AND IN VIVO STUDIES
(Pharmacy, 06-2 , Master Thesis)
Colorectal cancer (CRC) is one of the deadliest malignancies in the world. Despite improved treatment, CRC incidence and mortality rates have been increasing lately. Current conventional therapies are associated with severe ...
ANTICANCER EFFECTS OF MODIFIED CITRUS PECTIN AND CURCUMIN IN CHITOSAN NANOPARTICLES ON COLON CANCER
(Pharmacy, 06-2 , Master Thesis)
We aimed to study the influence of stirring effect while modifying citrus pectin
(CP), in addition to create a combination of curcumin in chitosan-modified citrus pectin
(CCM-NPs) nanoparticles, along with Galectin-3 in ...
DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL CHALCONE ANALOGS AS POTENTIAL THERAPEUTIC AGENTS FOR CASTRATION RESISTANT PROSTATE CANCER
(Pharmacy, 2021 , Master Thesis)
Prostate cancer (PCa) is the second most frequently diagnosed malignancy, as well as a leading cause of cancer-related mortality in men globally. Despite the initial response to hormonal targeted therapy, the majority of ...
IMPACT OF SGLT2 INHIBITORS ON CKD PROGRESSION IN DIABETIC PATIENTS IN QATAR A RETROSPECTIVE COHORT STUDY
(Pharmacy, 2023 , Master Thesis)
Background: The risk of end-stage renal disease rises is based on the estimated glomerular filtration rate (eGFR) reduction. Even though multiple large-scale clinical trials have demonstrated the preventive benefits of ...
HYPERTENSION MANAGEMENT AND PRESCRIBING PRACTICES IN PRIMARY HEALTHCARE SETTINGS IN QATAR: A MULTI-METHODS
(Pharmacy, 2023 , Master Thesis)
Background: The use of antihypertensive medications controls blood pressure (BP) and reduces the incidence of complications. This study explored the prescribing patterns and trends of antihypertensive medications utilization, ...
EXPLORATION OF THE APPLICATION OF PHARMACOGENETICS IN THE MANAGEMENT OF DEPRESSION
(Pharmacy, 2023 , Master Thesis)
Genetic factors have been reported as playing an important role in the treatment efficacy of antidepressants (ADs). Studies report up to 55 % of patients experience AD treatment failure. The aim of this research was to ...