Browsing Faculty Contributions by Author "Florento, Elena"
Now showing items 1-7 of 7
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Comparison of the biomarkers for targeted therapies in primary extra-mammary and mammary Paget's disease.
Gatalica, Zoran; Vranic, Semir; Krušlin, Božo; Poorman, Kelsey; Stafford, Phillip; Kacerovska, Denisa; Senarathne, Wijendra; Florento, Elena; Contreras, Elma; Leary, Alexandra; Choi, April; In, Gino K... more authors ... less authors ( Wiley Open Access , 2020 , Article)Primary Extra-mammary Paget's disease (EMPD) is a very rare cutaneous adenocarcinoma affecting anogenital or axillary regions. It is characterized by a prolonged course with recurrences and eventually distant metastatic ... -
Molecular Profiling of Clear Cell Carcinoma of the Breast Reveals Novel Targetable Biomarkers
Skenderi, Faruk; Palazzo, Juan; Swensen, Jeffrey; Contreras, Elma; Florento, Elena; Gatalica, Zoran; Vranic, Semir... more authors ... less authors ( Springer Nature , 2020 , Conference Paper)Background: Although clear cell morphology may be seen in various subtypes of breast cancer, a pure variant of clear cell carcinoma (usually glycogen-rich) is a very rare primary breast malignancy. It is characterized by ... -
Novel targetable biomarkers in clear cell carcinoma of the breast uncovered by molecular profiling: A study of nine cases.
Skenderi, Faruk; Palazzo, Juan; Swensen, Jeffrey; Feldman, Rebecca; Contreras, Elma; Florento, Elena; Gatalica, Zoran; Vranic, Semir... more authors ... less authors ( Wiley , 2020 , Article)We profiled nine pure clear cell carcinomas of the breast using massively parallel DNA and RNA sequencing (NGS), in situ hybridization (ISH), and immunohistochemistry (IHC). All cases were primary mammary clear cell ... -
Novel therapeutic targets in salivary duct carcinoma uncovered by comprehensive molecular profiling.
Gargano, Stacey M; Senarathne, Wijendra; Feldman, Rebecca; Florento, Elena; Stafford, Phillip; Swensen, Jeffrey; Vranic, Semir; Gatalica, Zoran... more authors ... less authors ( Wiley Open Access , 2019 , Article)Salivary duct carcinoma (SDC) is a rare, aggressive salivary gland malignancy, which often presents at an advanced stage. A proportion of SDC are characterized by HER2 amplification and/or overexpression of androgen receptor ... -
Potential Novel Therapy Targets in Neuroendocrine Carcinomas of the Breast.
Vranic, Semir; Palazzo, Juan; Sanati, Souzan; Florento, Elena; Contreras, Elma; Xiu, Joanne; Swensen, Jeffrey; Gatalica, Zoran... more authors ... less authors ( Elsevier , 2018 , Article)Neuroendocrine carcinoma (NEC) of the breast is a rare, special type of breast cancer, reportedly constituting 2% to 5% of all breast cancers. Although breast NEC does not have a specific targeted therapy, several new ... -
TERT gene fusions characterize a subset of metastatic Leydig cell tumors
Bozo, Kruslin; Gatalica, Zoran; Hes, Ondrej; Skenderi, Faruk; Miettinen, Markku; Contreras, Elma; Xiu, Joanne; Elis, Michelle; Florento, Elena; Vranic, Semir; Swensen, Jeffrey... more authors ... less authors ( Elsevier , 2021 , Article)Objective: Metastatic Leydig cell tumors (LCT) are rare, difficult to treat malignancies without known underlying molecular-genetic events. An index case of metastatic LCT showed an LDLR-TERT gene fusion upon routine genetic ... -
Theranostic molecular profiling of pleomorphic ductal carcinoma of the breast.
Vranic, Semir; Palazzo, Juan; Swensen, Jeffrey; Xiu, Joanne; Florento, Elena; Gatalica, Zoran... more authors ... less authors ( Wiley , 2019 , Other)Pleomorphic ductal carcinoma (PDC) is a very rare subtype of invasive ductal carcinoma of no‐special type (NST), characterized by the presence of highly atypical/bizarre (>6‐fold variation in nuclear size) and multinucleated ...