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Sulfated alginate/polycaprolactone double-emulsion nanoparticles for enhanced delivery of heparin-binding growth factors in wound healing applications
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Elsevier B.V.
, 2021 , Article)
Diabetic foot ulcers (DFUs) that are not effectively treated could lead to partial or complete lower limb amputations. The lack of connective tissue growth factor (CTGF) and insulin-like growth factor (IGF-I) in DFUs results ...
3D bioprinting of engineered breast cancer constructs for personalized and targeted cancer therapy
(
Elsevier B.V.
, 2021 , Article)
The bioprinting technique with specialized tissue production allows the study of biological, physiological, and behavioral changes of cancerous and non-cancerous tissues in response to pharmacological compounds in personalized ...
The therapeutic effects of tumor treating fields on cancer and noncancerous cells
(
Elsevier B.V.
, 2021 , Article)
Tumor treating fields (TTFields) are among clinically active anticancer modalities that utilize low?intensity, intermediate frequency (IF), and alternating electric fields (AEFs) to selectively disrupt mitosis in cancerous ...
Growth factor loaded in situ photocrosslinkable poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/gelatin methacryloyl hybrid patch for diabetic wound healing
(
Elsevier Ltd
, 2021 , Article)
Management of chronic diabetic ulcers remains as a major challenge in healthcare which requires extensive multidisciplinary approaches to ensure wound protection, management of excess wound exudates and promoting healing. ...
3D printed nanocomposites for tailored cardiovascular tissue constructs: A minireview
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Elsevier B.V.
, 2021 , Article)
Cardiovascular diseases (CVD) with escalating death rates pose one of the greatest threats to global health and well-being. Thus, developing effective interventions to combat CVD are of critical importance. 3D printing ...
Generation of gene edited hiPSC from familial Alzheimer's disease patient carrying N141I missense mutation in presenilin 2
(
Elsevier B.V.
, 2021 , Article)
Alzheimer's disease (AD) is the major cause of dementia worldwide. Early-onset familial AD accounts for about 0.5% of all AD and is caused by single major gene mutations and autosomal dominant inheritance. An N141I missense ...
A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin
(
Taylor and Francis Ltd.
, 2021 , Article)
The widespread antigenic changes lead to the emergence of a new type of coronavirus (CoV) called as severe acute respiratory syndrome (SARS)-CoV-2 that is immunologically different from the previous circulating species. ...
3D Bioprinted cancer models: Revolutionizing personalized cancer therapy
(
Neoplasia Press, Inc.
, 2021 , Article)
After cardiovascular disease, cancer is the leading cause of death worldwide with devastating health and economic consequences, particularly in developing countries. Inter-patient variations in anti-cancer drug responses ...
Active agents loaded extracellular matrix mimetic electrospun membranes for wound healing applications
(
Editions de Sante
, 2021 , Article)
Achieving the healing of chronic diabetic ulcers, burn wounds and large traumatic wounds is a major clinical challenge. A variety of approaches have been undertaken to generate skin substitutes, wound healing patches or ...
Gelatin-methacryloyl hydrogel based in vitro blood–brain barrier model for studying breast cancer-associated brain metastasis
(
Taylor and Francis Ltd.
, 2021 , Article)
Breast cancer is one of the leading causes of brain metastasis. Metastasis to the brain occurs if cancer cells manage to traverse the ‘blood-brain barrier’ (BBB), which is a barrier with a very tight junction (TJ) of ...