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Rational design of a multivalent vaccine targeting arthropod-borne viruses using reverse vaccinology strategies
(
Elsevier
, 2024 , Article)
Viruses transmitted by arthropods, such as Dengue, Zika, and Chikungunya, represent substantial worldwide health threats, particularly in countries like India. The lack of approved vaccines and effective antiviral therapies ...
Mangifera indica L. kernel ethanol extract inhibits cell viability and proliferation with induction of cell cycle arrest and apoptosis in lung cancer cells
(
Taylor and Francis Ltd.
, 2024 , Article)
In this study, we investigated the effects of an ethanolic extract of Mangifera indica L. kernel on the viability and proliferation of human lung cancer cells. We utilized MTT and BrdU cell proliferation assays, morphological ...
Imaging Patterns in Breast Cancer for Women Under 40 Years: A Descriptive Cohort Study
(
Springer Nature
, 2024 , Article)
Background and Aim: Breast cancer is the most frequently occurring malignant disease in women and remains the leading cause of cancer-related deaths among females worldwide. The aim of this study is to evaluate the imaging ...
Computational design of anti-cancer peptides tailored to target specific tumor markers
(
Springer Nature
, 2024 , Article)
Anti-cancer peptides (ACPs) are short peptides known for their ability to inhibit tumor cell proliferation, migration, and the formation of tumor blood vessels. In this study, we designed ACPs to target receptors often ...
In vivo testing of novel nitric oxide-releasing nanoparticles for alleviating heart failure using the zebrafish embryo model
(
Elsevier
, 2024 , Article)
Heart failure (HF) is a multifactorial, heterogeneous systemic disease that is considered one of the leading causes of death and morbidity worldwide. It is well-known that endothelial dysfunction (ED) plays an important ...
Metformin increases 3-hydroxy medium chain fatty acids in patients with type 2 diabetes: a cross-sectional pharmacometabolomic study
(
Frontiers Media SA
, 2024 , Article)
Background: Metformin is a drug with a long history of providing benefits in diabetes management and beyond. The mechanisms of action of metformin are complex, and continue to be actively debated and investigated. The aim ...
Breaking Barriers: The Promise and Challenges of Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2024 , Article Review)
Triple-negative breast cancer (TNBC) is a highly aggressive malignancy with pronounced immunogenicity, exhibiting rapid proliferation and immune cell infiltration into the tumor microenvironment. TNBC’s heterogeneity poses ...
Investigating Inflammatory Markers in Wound Healing: Understanding Implications and Identifying Artifacts
(
American Chemical Society (ACS)
, 2024 , Article)
Understanding the complex interplay of pro-inflammatory and anti-inflammatory cytokines is crucial in the field of wound healing, as it holds the key to developing effective therapeutics. In the initial stages of wound ...
Immune stimulatory effect of Nigella sativa in healthy animal models: A systematic review and meta-analysis
(
Elsevier Ltd
, 2024 , Article)
The immune-modulatory effects of black seeds (Nigella sativa seeds, NSS) are well documented, but the overall in vivo impact of this important natural medicinal product on immune system function has yet to be established. ...
Vitamin B12 deficiency in diabetic patients treated with metformin: A narrative review
(2024 , Article)
Metformin is the most prescribed oral hypoglycemic drug and is considered by many health practitioners as the first-line treatment for non-insulin-dependent diabetes mellitus (T2DM). It is used either as a monotherapy or ...