• English
    • العربية
  • العربية 
  • Login
  • QU
  • QU Library
  •  Home
  • Communities & Collections
  • Help
    • Item Submission
    • Publisher policies
    • User guides
    • FAQs
  • About QSpace
    • Vision & Mission
    • QSpace policies
Advanced Search
Advanced Search
View Item 
  •   Qatar University QSpace
  • Academic
  • Faculty Contributions
  • College of Health Sciences
  • Biomedical Sciences
  • View Item
  • Qatar University QSpace
  • Academic
  • Faculty Contributions
  • College of Health Sciences
  • Biomedical Sciences
  • View Item
  •      
  •  
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa

    Icon
    View/Open
    Author's accepted manuscript (1.270Mb)
    Date
    2017
    Author
    Majdalawieh, Amin F.
    Fayyad, Muneera W.
    Nasrallah, Gheyath K.
    Metadata
    Show full item record
    Abstract
    Over the past two decades, studies have documented the wide-range anti-cancer effects of Nigella sativa, known as black seed or black cumin. Thymoquinone (TQ), its major active ingredient, has also been extensively studied and reported to possess potent anti-cancer properties. Herein, we provide a comprehensive review of the findings related to the anti-cancer activity of TQ. The review focuses on analyzing experimental studies performed using different in vitro and in vivo models to identify the anti-proliferative, pro-apoptotic, anti-oxidant, cytotoxic, anti-metastatic, and NK-dependent cytotoxic effects exerted by TQ. In addition, we pinpoint the molecular mechanisms underlying these effects and the signal transduction pathways implicated by TQ. Our analysis show that p53, NF-κB, PPARγ, STAT3, MAPK, and PI3K/AKT signaling pathways are among the most significant pathways through which TQ mediates its anti-cancer activity. Experimental findings and recent advances in the field highlight TQ as an effective therapeutic agent for the suppression of tumor development, growth and metastasis for a wide range of tumors
    DOI/handle
    http://dx.doi.org/10.1080/10408398.2016.1277971
    http://hdl.handle.net/10576/5293
    Collections
    • Biomedical Sciences [‎269 ‎ items ]
    • Biomedical Research Center Research [‎287 ‎ items ]

    entitlement


    QSpace is a digital collection operated and maintained by the Qatar University Library and supported by the ITS department

    Contact Us | Send Feedback
    Contact Us | Send Feedback | QU

     

     

    Home

    Submit your QU affiliated work

    Browse

    All of QSpace
      Communities & Collections Publication Date Author Title Subject Type Language
    This Collection
      Publication Date Author Title Subject Type Language

    My Account

    Login

    Statistics

    View Usage Statistics

    About QSpace

    Vision & Mission QSpace policies

    Help

    Item Submission Publisher policiesUser guides FAQs

    QSpace is a digital collection operated and maintained by the Qatar University Library and supported by the ITS department

    Contact Us | Send Feedback
    Contact Us | Send Feedback | QU

     

     

    Video