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AuthorOuhtit, Allal
AuthorRizeq, Balsam
AuthorAbou Saleh, Haissam
AuthorRahman, MD Mizanur
AuthorZayed, Hatem
Available date2018-10-22T08:58:10Z
Publication Date2018
Publication NameInternational Journal of Biological Sciencesen_US
Identifierhttp://dx.doi.org/10.7150/ijbs.23586
CitationOuhtit A, Rizeq B, Saleh HA, Rahman MM, Zayed H. Novel CD44-downstream signaling pathways mediating breast tumor invasion. Int J Biol Sci 2018; 14(13):1782-1790. doi:10.7150/ijbs.23586. Available from http://www.ijbs.com/v14p1782.htm
URIhttp://hdl.handle.net/10576/11141
AbstractCD44, also known as homing cell adhesion molecule is a multi-structural cell molecule involved in cell-cell and cell-extracellular matrix communications. CD44 regulates a number of central signaling pathways, including PI3K/AKT, Rho GTPases and the Ras-MAPK pathways, but also acts as a growth/arrest sensor, and inhibitor of angiogenesis and invasion, in response to signals from the microenvironment. The function of CD44 has been very controversial since it acts as both, a suppressor and a promoter of tumor growth and progression. To address this discrepancy, we have previously established CD44-inducible system both in vitro and in vivo. Next, using microarray analysis, we have identified and validated Survivin, Cortactin and TGF-β2 as novel CD44-downstream target genes, and characterized their signaling pathways underpinning CD44-promoted breast cancer (BC) cell invasion. This report aims to update the literature by adding and discussing the impact of these novel three signaling pathways to better understand the CD44-signaling pathways involved in BC tumor cell invasion.
Languageen
PublisherIvyspring International Publisher
SubjectCD44
SubjectBreast cancer
SubjectCell-adhesion molecule
SubjectSurvivin
SubjectCortacti
TitleNovel CD44-downstream signaling pathways mediating breast tumor invasion
TypeArticle Review
Pagination1782-1790
Issue Number13
Volume Number14
dc.identifier.essn 1449-2288


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