Browsing Pharmacy Research by Author "Oberlies N.H."
Now showing items 1-3 of 3
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Cytotoxic homoisoflavonoids from the bulbs of Bellevalia flexuosa
El-Elimat T.; Rivera-Ch?vez J.; Burdette J.E.; Czarnecki A.; Alhawarri M.B.; Al-Gharaibeh M.; Alali F.; Oberlies N.H.... more authors ... less authors ( Elsevier B.V. , 2018 , Article)Four new homoisoflavonoids, 7-O-methyl-8-demethoxy-3′-hydroxy-3,9-dihydropunctatin (4), 6-hydroxy-8-demethoxy-4′-O-methyl-3,9-dihydropunctatin (8), 7,4′-O-dimethyl-8-demethoxy-3,3′-dihydroxy-3,9-dihydropunctatin (13), and ... -
Greensporone A, a fungal secondary metabolite suppressed constitutively activated AKT via ROS generation and induced apoptosis in leukemic cell lines
Prabhu K.S.; Siveen K.S.; Kuttikrishnan S.; Jochebeth A.; Ali T.A.; Elareer N.R.; Iskandarani A.; Khan A.Q.; Merhi M.; Dermime S.; El-Elimat T.; Oberlies N.H.; Alali F.Q.; Steinhoff M.; Uddin S.... more authors ... less authors ( MDPI AG , 2019 , Article)Greensporone A is a fungal secondary metabolite that has exhibited potential in vitro for anti-proliferative activity in vitro. We studied the anticancer activity of greensporone A in a panel of leukemic cell lines. ... -
Greensporone C, a Freshwater Fungal Secondary Metabolite Induces Mitochondrial-Mediated Apoptotic Cell Death in Leukemic Cell Lines
Prabhu K.S.; Siveen K.S.; Kuttikrishnan S.; Iskandarani A.N.; Khan A.Q.; Merhi M.; Omri H.E.; Dermime S.; El-Elimat T.; Oberlies N.H.; Alali F.Q.; Uddin S.... more authors ... less authors ( Frontiers Media S.A. , 2018 , Article)Therapeutic agents used in the treatment of cancer are known to develop resistance against cancer cells. Hence, there is a continuing need to investigate novel agents for the treatment and management of cancer. Antitumor ...