Browsing College of Medicine by Title
Now showing items 170-189 of 1337
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BRCA1 and Its Vulnerable C-Terminal BRCT Domain: Structure, Function, Genetic Mutations and Links to Diagnosis and Treatment of Breast and Ovarian Cancer
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)The BRCA1 is a tumor suppressor gene that encodes for the BRCA1 protein, which plays a vital role in DNA repair, cell cycle regulation, and the maintenance of genomic stability. The BRCA1 protein interacts with a variety ... -
Breast Cancer During Pregnancy: A Marked Propensity to Triple-Negative Phenotype.
( Frontiers Media , 2020 , Article)Breast and cervical cancers comprise 50% of all cancers during pregnancy. In particular, gestational breast cancer is considered one of the most aggressive types of cancers, which is a rare but fatal disease. However, the ... -
Breast Cancer Knowledge, Attitudes and Practices amongst Women in Qatar
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)This cross-sectional study examines knowledge, attitudes, and practices surrounding breast cancer awareness and screening among women residents in Qatar. Females, >18 years old, registered with the Primary Health Care ... -
Breast carcinoma metastasis suppressor gene 1 (BRMS1): update on its role as the suppressor of cancer metastases.
( Springer , 2015 , Article)BRMS1 was discovered over a decade ago as a potential tumor suppressor gene. In this review, we summarize the recent findings about the structure of BRMS1, mechanisms of its action and a role of BRMS1 in the cancer ... -
Breast lump as the initial presentation of metastatic uterine leiomyosarcoma: a case report and comprehensive literature review
( Medicinska Naklada Zagreb , 2024 , Article)Uterine leiomyosarcoma (uLMS) is a rare but aggressive cancer with a high metastatic potential and an unfavo-rable prognosis. A 54-year-old woman with a history of uterine fibroids clinically presented with a painless, ... -
Breath biopsy, a novel technology to identify head and neck squamous cell carcinoma: A systematic review
( Wiley , 2022 , Article Review)Head and neck cancers are a heterogeneous group of neoplasms, which together comprise the sixth most common cancer globally. Breath biopsies are a non-invasive clinical investigation that detect volatile organic compounds ... -
Bridging conventional medicine and traditional, complementary, and alternative approaches: Fostering collaborative attempts for a holistic healthcare system
( Elsevier , 2023 , Other)Dear Editor, We read the paper entitled “The future of integrative health: vision, values, and principles for positive, sustainable systemic change” by Kemper, which was published last month.1 The points discussed therein ... -
Brief psychotic disorder associated with quarantine and mild COVID-19
( BMJ Publishing Group , 2020 , Article)A 30-year-old man with no significant previous or family psychiatric history became severely anxious about his health after a positive COVID-19 test. Physical symptoms of COVID-19 were mild, with no evidence of hypoxia or ... -
Burden and disease pathogenesis of influenza and other respiratory viruses in diabetic patients
( Elsevier , 2022 , Article Review)Over the past two decades, diabetes mellitus (DM) has been receiving increasing attention among autoimmune diseases. The prevalence of type 1 and type 2 diabetes has increased rapidly and has become one of the leading ... -
Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021
( Elsevier , 2024 , Article)BackgroundFuture trends in disease burden and drivers of health are of great interest to policy makers and the public at large. This information can be used for policy and long-term health investment, planning, and ... -
Burnout and job satisfaction among psychiatrists in the Mental Health Service, Hamad Medical Corporation, Qatar
( Elsevier , 2021 , Article)Background: Job satisfaction is a critical concern among medical staff and directly affects patient safety and quality of health care services. Burnout has been reported to be correlated with job satisfaction. Aims: This ... -
Buspirone in the management of refractory irritable bowel syndrome A case report
( Lippincott Williams and Wilkins , 2021 , Article)Rationale: Irritable bowel syndrome (IBS) is a chronic and debilitating functional disorder of the gastrointestinal tract manifested by abdominal pain and bowel habit dysregulation. The pathophysiology is complex and ... -
C-peptide in diabetes: A player in a dual hormone disorder?
( Wiley-Blackwell , 2024 , Article)C-peptide, a byproduct of insulin synthesis believed to be biologically inert, is emerging as a multifunctional molecule. C-peptide serves an anti-inflammatory and anti-atherogenic role in type 1 diabetes mellitus (T1DM) ... -
Calmodulin Interacts and Regulates Enzyme Activity of the Mammalian Sperm Phospholipase C
( Elsevier , 2017 , Article)Sperm-specific Phospholipase C zeta (PLCζ) is widely considered to be the sole, physiological stimulus responsible for the generation of Ca2+ oscillations that induce egg activation and early embryo development during ... -
Calmodulin Mutations Associated with Congenital Cardiac Disease Display Novel Biophysical and Biochemical Characteristics
( Elsevier , 2018 , Article)Calmodulin (CaM) is a cytoplasmic multifunctional calcium (Ca2+)-binding messenger that interacts with the cardiac ryanodine receptor (RyR2), a large transmembrane Ca2+ channel that mediates Ca2+ release from the sarcoplasmic ... -
Can atorvastatin with metformin change the natural history of prostate cancer as characterized by molecular, metabolomic, imaging and pathological variables? A randomized controlled trial protocol
( Elsevier , 2016 , Article)Background Atorvastatin and metformin are known energy restricting mimetic agents that act synergistically to produce molecular and metabolic changes in advanced prostate cancer (PCa). This trial seeks to determine whether ... -
Cannabinoids and Myocardial Ischemia: Novel insights, Updated Mechanisms, and Implications for Myocardial Infarction
( Bentham Science Publishers , 2022 , Article)Cannabis is the most widely trafficked and abused illicit drug due to its calming psychoactive properties. It has been increasingly recognized as having potential health benefits and relatively less adverse health effects ... -
Carbimazole-Induced Jaundice in Thyrotoxicosis: A Case Report.
( Springer , 2021 , Article)Carbimazole is a commonly used antithyroid drug in thyrotoxicosis. It is generally well tolerated, and its side effects include allergic skin reactions, gastrointestinal upset, agranulocytosis, and hepatotoxicity. Hepatitis ... -
Carcinoma with apocrine differentiation
( World Health Organization , 2019 , Book chapter)Carcinoma with apocrine differentiation is a rare subtype constituting ~1% of all invasive breast carcinomas. Patients tend to be older compared with patients with invasive breast carcinomas NST. Essential criteria: Invasive ... -
Cardiac Arrest in an Adolescent Boy Due to the Anomalous Origin of the Left Main Coronary Artery: Emergency Department Perspective.
( Cureus , 2022 , Article)Congenital anomalies of the origin of the coronary arteries are rare. Multiple anomalies have been reported where the common one is left circumflex arising from the right sinus of Valsalva (RSV). Other anomalies are a ...
