Browsing College of Medicine by Subject "Metastasis"
Now showing items 1-6 of 6
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Breast carcinoma metastasis suppressor gene 1 (BRMS1): update on its role as the suppressor of cancer metastases.
( Springer , 2015 , Article)BRMS1 was discovered over a decade ago as a potential tumor suppressor gene. In this review, we summarize the recent findings about the structure of BRMS1, mechanisms of its action and a role of BRMS1 in the cancer ... -
Choroidal metastasis as initial presentation of aggressive medullary thyroid carcinoma with widespread mediastinal, brain, pituitary, bone, lung, and liver metastasis: Case report and literature review
( Elsevier , 2021 , Article)Introduction Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor that originates from the parafollicular C cells of the thyroid gland. MTC can be due to sporadic or hereditary causes due to gain of function germ ... -
Composition of the immune microenvironment differs between carcinomas metastatic to the lungs and primary lung carcinomas.
( Elsevier , 2018 , Article)Lungs are among the most common sites for development of both primary and metastatic carcinomas. Tumor cells expression (TC) of PD-L1 is an important predictor of the of response to immune check-point inhibition in NSCLC, ... -
Contribution of Glycosaminoglycan binding in CCL21-mediated Migration of Breast Cancer cells
( Qatar University Press , 2021 , Poster)Lymph node metastasis constitutes a key event in Breast Cancer progression and it is a process at least partially mediated by the chemokine CCR7. Chemokine function is dependent upon their binding to both cell-surface ... -
RKIP in human diseases and its potential as a prognostic indicator and therapeutic target
( Elsevier , 2020 , Book chapter)The Raf kinase inhibitory protein (RKIP) is an inhibitor of the RAF/MEK/ERK and NF-κB signaling pathways, through which it regulates several key processes of the cell's physiology, such as its proliferation, motility and ... -
Snornas and mirnas networks underlying covid-19 disease severity
( MDPI , 2021 , Article)There is a lack of predictive markers for early and rapid identification of disease progression in COVID-19 patients. Our study aims at identifying microRNAs (miRNAs)/small nucleolar RNAs (snoRNAs) as potential biomarkers ...