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Biomarkers of Targeted Therapy and Immuno-Oncology in Cancers Metastatic to the Breast.
(
Lippincott, Williams & Wilkins
, 2019 , Article)
The breast is a rare site for metastases, and their molecular characteristics have not been studied yet. Intrinsic molecular genetics, cancer characteristics, and breast tissue immune responses in diverse metastases to the ...
Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response.
(
Springer Nature
, 2019 , Article)
Signaling diversity of G protein-coupled (GPCR) ligands provides novel opportunities to develop more effective, better-tolerated therapeutics. Taking advantage of these opportunities requires identifying which effectors ...
Efficacy of sodium-glucose co-transporter 2 inhibitors in patients with type II diabetes: A protocol for systematic review of randomised controlled clinical trials utilising a generalised pairwise modelling methodology.
(
Wolters Kluwer Health, Inc.
, 2019 , Article)
Recent systematic reviews have evaluated the efficacy of sodium-glucose co-transporter 2 inhibitors (SGLT2) inhibitors (SGLT2I) in improving glycaemic control and mortality in patients with type II diabetes mellitus. None ...
Failed immune responses across multiple pathologies share pan-tumor and circulating lymphocytic targets
(
American Society for Clinical Investigation
, 2019 , Article)
Tumor-infiltrating lymphocytes (TILs) are widely associated with positive outcomes, yet carry key indicators of a systemic failed immune response against unresolved cancer. Cancer immunotherapies can reverse their tolerance ...
Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivity
(
American Society for Clinical Investigation
, 2019 , Article)
Itch induces scratching that removes irritants from the skin, whereas pain initiates withdrawal or avoidance of tissue damage. While pain arises from both the skin and viscera, we investigated whether pruritogenic irritant ...
Maspin differential expression patterns as a potential marker for targeted screening of esophageal adenocarcinoma/gastroesophageal junction adenocarcinoma.
(
Public Library of Science
, 2019 , Article)
Barrett's esophagus (BE) is a predisposing factor of esophageal adenocarcinoma/gastroesophageal junction adenocarcinoma (ECA/GEJ Aca). BE patients are stratified and subsequently monitored according to the risk of malignant ...
Novel Epigenetic Biomarkers in Pregnancy-Related Disorders and Cancers
(
MDPI
, 2019 , Article)
As the majority of cancers and gestational diseases are prognostically stage- and grade-dependent, the ultimate goal of ongoing studies in precision medicine is to provide early and timely diagnosis of such disorders. These ...
Immunomodulatory Effects of Vitamin D in Pregnancy and Beyond.
(
Frontiers Media
, 2019 , Article)
In addition to its role in calcium homeostasis and bone formation, a modulatory role of the active form of vitamin D on cells of the immune system, particularly T lymphocytes, has been described. The effects of vitamin D ...
Mucocele of the appendix presenting as an exacerbated chronic tubo-ovarian abscess: A case report and comprehensive review of the literature.
(
Lippincott, Williams & Wilkins
, 2019 , Article)
Appendiceal mucocele is a rare entity of mucinous cystic dilatation of the appendix. It has no typical clinical presentation and is considered a potentially premalignant condition. We present a case of accidental intraoperative ...
Investigating the blood-host plasticity and dispersal of Anopheles coluzzii using a novel field-based methodology
(
BioMed Central Ltd.
, 2019 , Article)
Background: The biting behaviour and dispersal of insect vectors in the field underlies the transmission of many diseases. Here, a novel collection methodology coupled with the molecular analysis of blood-meal sources and ...