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Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease
(
BioMed Central
, 2016 , Article)
Background
Despite decades of intensive research, to date, there is no accepted diagnosis for Parkinson’s disease (PD) based on biochemical analysis of blood or CSF. However, neurodegeneration in the brains of PD patients ...
Cerebrospinal fluid α-synuclein species in cognitive and movements disorders
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2021 , Article)
Total CSF α-synuclein (t-α-syn), phosphorylated α-syn (pS129-α-syn) and α-syn oligomers (o-α-syn) have been studied as candidate biomarkers for synucleinopathies, with suboptimal specificity and sensitivity in the ...