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Macrophage responses associated with COVID-19: A pharmacological perspective
(
Elsevier
, 2020 , Article)
COVID-19 has caused worldwide death and economic destruction. The pandemic is the result of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has demonstrated high rates of infectivity leading to great ...
Phytochemicals as Micronutrients: What Is their Therapeutic Promise in the Management of Traumatic Brain Injury?
(
Springer Singapore
, 2022 , Book chapter)
Traumatic brain injury (TBI) is one of the key causes of deaths and disabilities worldwide. TBI progresses in two phases. The primary phase of injury is the direct result of the physical damage caused by the external force ...
Phytochemicals as Micronutrients: What Is their Therapeutic Promise in the Management of Alzheimer’s Disease?
(
Springer Singapore
, 2022 , Book chapter)
Alzheimer’s disease (AD) is a debilitating neurodegenerative disease with devastating outcomes to patients and exhaustive burdens to healthcare systems. Alzheimer’s disease has always been the focus of extensive research ...
Diagnostic Value of Non-invasive Liver Function Tests in Liver Fibrosis and Changes in These Parameters Post-metabolic Surgery
(
Springer
, 2023 , Article)
Purpose: This study aimed to ascertain the diagnostic accuracy of non-invasive liver function tests in liver fibrosis and assess their changes after metabolic surgery. Materials and Methods: 1005 individuals with severe ...
Early metabolic impairment as a contributor to neurodegenerative disease: Mechanisms and potential pharmacological intervention
(
Wiley
, 2022 , Article Review)
The metabolic syndrome comprises a family of clinical and laboratory findings, including insulin resistance, hyperglycemia, hypertriglyceridemia, low high-density lipoprotein cholesterol levels, and hypertension, in addition ...
Therapeutic effects of statins on osteoarthritis: A review
(
Wiley
, 2022 , Article Review)
Osteoarthritis (OA) is a progressive joint disease. The etiology of OA is considered to be multifactorial. Currently, there is no definitive treatment for OA, and the existing treatments are not very effective. ...
Drug Repurposing in Vasculo-metabolic Diseases
(
Bentham Science Publishers
, 2023 , Other)
Drug repurposing or repositioning is an approach that seeks to maximize the use of existing drugs by identifying
new indications other than the ones for which the drug was initially conceived [1-5]. This approach has been ...
Effects of Trehalose Administration in Patients with Mucopolysaccharidosis Type III.
(
Europe PMC
, 2023 , Article)
Mucopolysaccharidosis type III (MPS III) is a rare autosomal recessive lysosomal storage disease (LSD) caused by a deficiency of lysosomal enzymes required for the catabolism of glycosaminoglycans (GAGs), mainly in the ...
MicroRNA-mediated regulation of LDL receptor: biological and pharmacological implications.
(
Europe PM
, 2023 , Article)
One of the main causes of atherosclerosis is a disruption in cellular cholesterol hemostasis. The low-density lipoprotein receptor (LDLR) is an important factor in maintaining cholesterol homeostasis by the receptor-mediated ...
Cardioprotective Effect of Rheum turkestanicum Against Doxorubicin-Induced Toxicity in Rats
(
Frontiers Media S.A.
, 2022 , Article)
Background: Doxorubicin as an anti-cancer drug causes cardiotoxicity, limiting its tolerability and use. The mechanism of toxicity is due to free radical production and cardiomyocytes injury. This research evaluated Rheum ...