تصفح Biomedical Sciences حسب المؤلف "Elbayaa, Rasha Y."
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Novel 1,5-diphenyl-6-substituted 1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones induced apoptosis in RKO colon cancer cells
Malki, Ahmed; Ashour, Hayam M. A.; Elbayaa, Rasha Y.; Issa, Doaa A. E.; Aziz, Hassan A.; Chen, Xiaozhuo... more authors ... less authors ( Taylor and Francis Ltd , 2016 , Article)Novel 1,5-diphenyl-6-substituted-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones were synthesized and characterized. All compounds were screened for their anti-proliferative activities in five different cancer cell lines. The results ... -
Novel Quinuclidinone Derivatives Induced Apoptosis in Human Breast Cancer via Targeting P53
Malki, Ahmed; Elbayaa, Rasha Y.; Ali, Omnia; Sultan, Ahmed; Youssef, Amal M. ( Elsevier , 2017 , Article)Small molecules that can target human cancers have been highly sought to increase the anticancer efficacy, the present work describes the design and synthesis of novel series of five quinuclidinone derivatives (2a-2e). ... -
Novel thiosemicarbazides induced apoptosis in human MCF-7 breast cancer cells via JNK signaling
Malki, Ahmed; Elbayaa, Rasha Y.; Ashour, Hayam M.A.; Loffredo, Christopher A.; Youssef, Amal M. ( Taylor & Francis , 2015 , Article)In this study, novel thiosemicarbazides and 1,3,4-oxadiazoles were synthesized and evaluated for their anticancer effects on human MCF-7 breast cancer cell lines. Among the synthesized derivatives studied, compound ...