Browsing Health Sciences-CAS (pre 2016) by Author "Al-Shabrawey, Mohamed"
Now showing items 1-3 of 3
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12/15-Lipoxygenase-Derived Lipid Metabolites Induce Retinal Endothelial Cell Barrier Dysfunction: Contribution of NADPH Oxidase
Othman, Amira; Ahmad, Saif; Megyerdi, Sylvia; Mussell, Rene; Choksi, Karishma; Maddipati, Krishna Rao; Elmarakby, Ahmed; Rizk, Nasser; Al-Shabrawey, Mohamed... more authors ... less authors ( Public Library of Science , 2013 , Article)The purpose of the current study was to evaluate the effect of 12/15- lipoxygenase (12/15-LOX) metabolites on retinal endothelial cell (REC) barrier function. FITC-dextran flux across the REC monolayers and electrical ... -
A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase
Ibrahim, Ahmed S.; Elshafey, Sally; Sellak, Hassan; Hussein, Khaled A.; El-Sherbiny, Mohamed; Abdelsaid, Mohammed; Rizk, Nasser; Beasley, Selina; Tawfik, Amany M.; Smith, Sylvia B.; Al-Shabrawey, Mohamed... more authors ... less authors ( American Society for Biochemistry and Molecular Biology , 2015 , Article)Retinal hyperpermeability and subsequent macular edema is a cardinal feature of early diabetic retinopathy (DR). Here, we investigated the role of bioactive lipid metabolites, in particular 12/15-lipoxygenase (LOX)-derived ... -
Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids
Ibrahim, Ahmed S.; Tawfik, Amany M.; Hussein, Khaled A.; Elshafey, Sally; Markand, Shanu; Rizk, Nasser; Duh, Elia J.; Smith, Sylvia B.; Al-Shabrawey, Mohamed... more authors ... less authors ( Elsevier , 2015 , Article)We recently demonstrated that 12/15-lipoxygenase (LOX) derived metabolites, hydroxyeicosatetraenoic acids (HETEs), contribute to diabetic retinopathy (DR) via NADPH oxidase (NOX) and disruption of the balance in retinal ...