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المؤلفMarei, Hany E
المؤلفHasan, A
المؤلفRizzi, R
المؤلفAlthani, A
المؤلفAfifi, N
المؤلفCenciarelli, C
المؤلفCaceci, Thomas
المؤلفShuaib, Ashfaq
تاريخ الإتاحة2018-02-27T05:04:50Z
تاريخ النشر2018-02-06
اسم المنشورFrontiers in Neurologyen_US
المعرّفhttp://dx.doi.org/10.3389/fneur.2018.00034
الاقتباسMarei HE, Hasan A, Rizzi R, Althani A, Afifi N, Cenciarelli C, Caceci T and Shuaib A (2018) Potential of Stem Cell-Based Therapy for Ischemic Stroke. Front. Neurol. 9:34. doi: 10.3389/fneur.2018.00034
معرّف المصادر الموحدhttp://hdl.handle.net/10576/6406
الملخصIschemic stroke is one of the major health problems worldwide. The only FDA approved anti-thrombotic drug for acute ischemic stroke is the tissue plasminogen activator. Several studies have been devoted to assessing the therapeutic potential of different types of stem cells such as neural stem cells (NSCs), mesenchymal stem cells, embryonic stem cells, and human induced pluripotent stem cell-derived NSCs as treatments for ischemic stroke. The results of these studies are intriguing but many of them have presented conflicting results. Additionally, the mechanism(s) by which engrafted stem/progenitor cells exert their actions are to a large extent unknown. In this review, we will provide a synopsis of different preclinical and clinical studies related to the use of stem cell-based stroke therapy, and explore possible beneficial/detrimental outcomes associated with the use of different types of stem cells. Due to limited/short time window implemented in most of the recorded clinical trials about the use of stem cells as potential therapeutic intervention for stroke, further clinical trials evaluating the efficacy of the intervention in a longer time window after cellular engraftments are still needed.
راعي المشروعGCC-2017-004 Internal Grant Qatar University
اللغةen
الناشرFrontiers Media
الموضوعinduced pluripotent stem cells
الموضوعischemic stroke
الموضوعmesenchymal stem cell
الموضوعneural stem cell
الموضوعstem cell
العنوانPotential of Stem Cell-Based Therapy for Ischemic Stroke.
النوعArticle
الصفحات1-7
رقم المجلد9
dc.identifier.essn 1664-2295


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