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AuthorBedri, Shahinaz
AuthorSultan, Ali A
AuthorAlkhalaf, Moussa
AuthorAl Moustafa, Ala-Eddin
AuthorVranic, Semir
Available date2019-04-04T08:54:37Z
Publication Date2018-10-31
Publication NameHuman Vaccines and Immunotherapeuticsen_US
Identifierhttp://dx.doi.org/10.1080/21645515.2018.1543525
CitationShahinaz Bedri, Ali A. Sultan, Moussa Alkhalaf, Ala-Eddin Al Moustafa & Semir Vranic (2019) Epstein-Barr virus (EBV) status in colorectal cancer: a mini review, Human Vaccines & Immunotherapeutics, 15:3, 603-610, DOI: 10.1080/21645515.2018.1543525
ISSN2164-5515
URIhttp://hdl.handle.net/10576/11473
AbstractEpstein-Barr virus (EBV) is a well-characterized oncovirus, associated with several malignancies. The complex and heterogeneous nature of colorectal cancer (CRC) has led to many epidemiological causal associations with CRC. However, a direct causal link between microbial infections and CRC has not been established yet. Our review indicates that the current evidence for the presence and role in EBV in CRC is insufficient and contradictory. The design of the analyzed studies, sample size as well as methodology used for EBV detection varied markedly and consequently may not lead to meaningful conclusions. The presence of EBV in other colorectal tumors (lymphomas, smooth muscle tumors) is in line with their status at other anatomic locations and may have therapeutic implications with EBV-specific vaccines. On the other hand, studies exploring EBV in colorectal adenoma-carcinoma sequence and its molecular genetic characteristics are largely missing and may significantly contribute to a better understanding of the role of EBV in CRC.
Languageen
PublisherTaylor & Francis
SubjectColorectal cancer
SubjectEpstein-Barr virus
Subjectmicrobes
Subjectreview
TitleEpstein-Barr virus (EBV) status in colorectal cancer: a mini review
TypeArticle
Pagination603-610
Issue Number3
Issue Number3
Volume Number15
Volume Number15
ESSN2164-554X


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