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AuthorBhuiyan T.A.
AuthorGraff C.
AuthorKanters J.K.
AuthorMelgaard J.
AuthorToft E.
AuthorK??b S.
AuthorStruijk J.J.
Available date2019-09-30T07:47:43Z
Publication Date2018
Publication NameClinical Pharmacology and Therapeutics
AbstractThe hypothesis of the study is that Torsades de pointes (TdP) history can be better identified using T-wave morphology compared to Fridericia-corrected QT interval (QTcF) at baseline. ECGs were recorded at baseline and during sotalol challenge in 20 patients with a history of TdP (+TdP) and 16 patients without previous TdP (–TdP). The QTcF and T-wave morphology combination score (MCS) were calculated. At baseline, there was no significant difference in QTcF between the groups (+TdP: QTcF = 446 ± 9 ms; –TdP: QTcF = 431 ± 9 ms, P = 0.27). In contrast, MCS was significantly different between the groups at baseline (+TdP: MCS = 1.07 ± 0.095; –TdP: MCS = 0.74 ± 0.07, P = 0.012). Both QTcF and MCS could be used to discriminate between +TdP and –TdP after sotalol but only MCS reached statistical significance at baseline. Combining QTcF with MCS provided a significantly larger difference between groups than QTcF alone. © 2017 American Society for Clinical Pharmacology and Therapeutics
SponsorThis work was supported by the Danish Council for Strategic Research (HEARTSAFE Grant Number: 10-092799). 22. Drew, B.J. et al. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. Circulation. 121, 1047� 1060 (2010).
PublisherNature Publishing Group
TitleA History of Drug-Induced Torsades de Pointes Is Associated With T-wave Morphological Abnormalities
Issue Number6
Volume Number103

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