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AuthorAugustine, Robin
AuthorHasan, Anwarul
AuthorPatan, Noorunnisa Khanam
AuthorAugustine, Anitha
AuthorDalvi, Yogesh B
AuthorVarghese, Ruby
AuthorUnni, Raghunath Narayanan
AuthorKalarikkal, Nandakumar
AuthorAl Moustafa, Ala-Eddin
AuthorThomas, Sabu
Available date2019-10-16T05:48:44Z
Publication Date2019-07-01
Publication NameMacromolecular Bioscienceen_US
CitationAugustine, R., Hasan, A., Patan, N. K., Augustine, A., Y. B Dalvi, , Varghese, R., Unni, R. N., Kalarikkal, N., Al Moustafa, A.‐E., Thomas, S., Titanium Nanorods Loaded PCL Meshes with Enhanced Blood Vessel Formation and Cell Migration for Wound Dressing Applications. Macromol. Biosci. 2019, 19, 1900058.
AbstractProper management of nonhealing wounds is an imperative clinical challenge. For the effective healing of chronic wounds, suitable wound coverage materials with the capability to accelerate cell migration, cell proliferation, angiogenesis, and wound healing are required to protect the healing wound bed. Biodegradable polymeric meshes are utilized as effective wound coverage materials to protect the wounds from the external environment and prevent infections. Among them, electrospun biopolymeric meshes have got much attention due to their extracellular matrix mimicking morphology, ability to support cell adhesion, and cell proliferation. Herein, electrospun nanocomposite meshes based on polycaprolactone (PCL) and titanium dioxide nanorods (TNR) are developed. TNR incorporated PCL meshes are fabricated by electrospinning technique and characterized by scanning electron microscopy, energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy (FTIR) analysis, and X-Ray diffraction (XRD) analysis. In vitro cell culture studies, in ovo angiogenesis assay, in vivo implantation study, and in vivo wound healing study are performed. Interestingly, obtained in vitro and in vivo results demonstrated that the presence of TNR in the PCL meshes greatly improved the cell migration, proliferation, angiogenesis, and wound healing. Owing to the above superior properties, they can be used as excellent biomaterials in wound healing and tissue regeneration applications.
SponsorThis article was made possible by the NPRP9‐144‐3‐021 grant funded by Qatar National Research Fund (a part of Qatar Foundation). The statements made here are totally responsibility of authors.
SubjectTiO2 nanorods
Subjectwound dressings
TitleTitanium Nanorods Loaded PCL Meshes with Enhanced Blood Vessel Formation and Cell Migration for Wound Dressing Applications.
Issue Number7
Volume Number19

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