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Vitamin D and Its Potential Interplay With Pain Signaling Pathways
(
Frontiers Media
, 2020 , Article Review)
About 50 million of the U.S. adult population suffer from chronic pain. It is a complex disease in its own right for which currently available analgesics have been deemed woefully inadequate since ~20% of the sufferers ...
IP3 receptors and their intimate liaisons
(
Elsevier
, 2020 , Article Review)
Inositol 1,4,5-trisphosphate receptors (IP3Rs) are intracellular Ca2+ channels. They allow cell-surface receptors that stimulate IP3 formation to evoke rapid Ca2+ release from the endoplasmic reticulum (ER). IP3Rs initiate ...
The store-operated Ca entry complex comprises a small cluster of STIM1 associated with one Orai1 channel.
(
National Academy of Sciences
, 2021 , Article)
Increases in cytosolic Ca concentration regulate diverse cellular activities and are usually evoked by opening of Ca channels in intracellular Ca stores and the plasma membrane (PM). For the many signals that evoke formation ...
KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals
(
Nature Research
, 2021 , Article)
Regulation of IP3 receptors (IP3Rs) by IP3 and Ca2+ allows regenerative Ca2+ signals, the smallest being Ca2+ puffs, which arise from coordinated openings of a few clustered IP3Rs. Cells express thousands of mostly mobile ...