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P-value driven methods were underpowered to detect publication bias: analysis of Cochrane review meta-analyses
(
Elsevier
, 2019 , Article)
To investigate the effect of number of studies in a meta-analysis on the detection of publication bias using p-value driven methods. The proportion of meta-analyses detected by Egger's, Harbord's, Peters', and Begg's tests ...
Utilization of the evidence from studies with no events in meta-analyses of adverse events: an empirical investigation
(
Springer
, 2021 , Article)
Zero-events studies frequently occur in systematic reviews of adverse events, which consist of an important source of evidence. We aimed to examine how evidence of zero-events studies was utilized in the meta-analyses of ...
The odds ratio is “portable” but not the relative risk: Time to do away with the log link in binomial regression
(
Elsevier
, 2021 , Article)
Objectives: In a recent paper we suggest that the relative risk (RR) be replaced with the odds ratio (OR) as the effect measure of choice in clinical epidemiology. In response, Chu, and colleagues raise several points that ...
Rapid evidence synthesis approach for limits on the search date: how rapid could it be?
(
John Wiley and Sons
, 2021 , Article)
Rapid reviews have been widely employed to support timely decision-making, and limiting the search date is the most popular approach in published rapid reviews. We assessed the accuracy and workload of search date limits ...
Synthesis of evidence from zero-events studies: A comparison of one-stage framework methods
(
John Wiley & Sons, Ltd
, 2021 , Article)
In evidence synthesis, dealing with zero-events studies is an important and complicated task that has generated broad discussion. Numerous methods provide valid solutions to synthesizing data from studies with zero-events, ...
Controversy and Debate: Questionable utility of the relative risk in clinical research: Paper 1: A call for change to practice
(
Elsevier
, 2020 , Article)
Background and Objectives
In clinical trials, the relative risk or risk ratio (RR) is a mainstay of reporting of the effect magnitude for an intervention. The RR is the ratio of the probability of an outcome in an ...